Effect of perioperative analgesia on immunity in lung cancer
COX inhibitors are frequently used for pain management during the perioperative period and may influence tumor progression and the tumor microenvironment by modulating inflammation and immune responses. This study investigates the effects of COX inhibitors on tumor growth and the immune microenviron...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Immunobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171298525000014 |
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| _version_ | 1850252969810853888 |
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| author | Xiaomin Fan Ziqi Huang Ziying Chen Liang Yun Xinjian Zhang |
| author_facet | Xiaomin Fan Ziqi Huang Ziying Chen Liang Yun Xinjian Zhang |
| author_sort | Xiaomin Fan |
| collection | DOAJ |
| description | COX inhibitors are frequently used for pain management during the perioperative period and may influence tumor progression and the tumor microenvironment by modulating inflammation and immune responses. This study investigates the effects of COX inhibitors on tumor growth and the immune microenvironment. In vivo experiments demonstrate that COX inhibitors can reduce tumor cell growth, elevate PD-L1 expression on tumor cells, and enhance the proportion of myeloid cells within the tumor immune microenvironment. Furthermore, COX inhibitors are found to improve the efficacy of the immune checkpoint inhibitor anti-PD-L1. These results underscore the influence of perioperative COX inhibitors on tumor immunity and suggest potential new strategies for optimizing tumor immunotherapy. |
| format | Article |
| id | doaj-art-23b300b39d12435188932d1f3bbd7900 |
| institution | OA Journals |
| issn | 0171-2985 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Immunobiology |
| spelling | doaj-art-23b300b39d12435188932d1f3bbd79002025-08-20T01:57:31ZengElsevierImmunobiology0171-29852025-03-01230215286710.1016/j.imbio.2025.152867Effect of perioperative analgesia on immunity in lung cancerXiaomin Fan0Ziqi Huang1Ziying Chen2Liang Yun3Xinjian Zhang4Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Radiation Oncology, Shenzhen Longgang Central Hospital of Shenzhen, Shenzhen, ChinaThe first clinical medical college, Southern Medical University, Guangzhou, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Corresponding author.COX inhibitors are frequently used for pain management during the perioperative period and may influence tumor progression and the tumor microenvironment by modulating inflammation and immune responses. This study investigates the effects of COX inhibitors on tumor growth and the immune microenvironment. In vivo experiments demonstrate that COX inhibitors can reduce tumor cell growth, elevate PD-L1 expression on tumor cells, and enhance the proportion of myeloid cells within the tumor immune microenvironment. Furthermore, COX inhibitors are found to improve the efficacy of the immune checkpoint inhibitor anti-PD-L1. These results underscore the influence of perioperative COX inhibitors on tumor immunity and suggest potential new strategies for optimizing tumor immunotherapy.http://www.sciencedirect.com/science/article/pii/S0171298525000014Perioperative analgesiaCOX inhibitorImmune checkpointLung adenocarcinomaTumor microenvironment |
| spellingShingle | Xiaomin Fan Ziqi Huang Ziying Chen Liang Yun Xinjian Zhang Effect of perioperative analgesia on immunity in lung cancer Immunobiology Perioperative analgesia COX inhibitor Immune checkpoint Lung adenocarcinoma Tumor microenvironment |
| title | Effect of perioperative analgesia on immunity in lung cancer |
| title_full | Effect of perioperative analgesia on immunity in lung cancer |
| title_fullStr | Effect of perioperative analgesia on immunity in lung cancer |
| title_full_unstemmed | Effect of perioperative analgesia on immunity in lung cancer |
| title_short | Effect of perioperative analgesia on immunity in lung cancer |
| title_sort | effect of perioperative analgesia on immunity in lung cancer |
| topic | Perioperative analgesia COX inhibitor Immune checkpoint Lung adenocarcinoma Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S0171298525000014 |
| work_keys_str_mv | AT xiaominfan effectofperioperativeanalgesiaonimmunityinlungcancer AT ziqihuang effectofperioperativeanalgesiaonimmunityinlungcancer AT ziyingchen effectofperioperativeanalgesiaonimmunityinlungcancer AT liangyun effectofperioperativeanalgesiaonimmunityinlungcancer AT xinjianzhang effectofperioperativeanalgesiaonimmunityinlungcancer |