Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis
Abstract Osteoporosis is a systemic metabolic degenerative bone disease characterised by decreased bone mass, impaired bone microstructure, weakened bone strength and susceptibility to fracture. In China, the prevention and treatment of osteoporosis is faced with a high disease prevalence rate but l...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-05879-w |
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| author | Bo Liu Xue Mao Zhe-Jian-Yi Gao Huan Wang |
| author_facet | Bo Liu Xue Mao Zhe-Jian-Yi Gao Huan Wang |
| author_sort | Bo Liu |
| collection | DOAJ |
| description | Abstract Osteoporosis is a systemic metabolic degenerative bone disease characterised by decreased bone mass, impaired bone microstructure, weakened bone strength and susceptibility to fracture. In China, the prevention and treatment of osteoporosis is faced with a high disease prevalence rate but low awareness, diagnosis and treatment rates. Bone resorption inhibitors and bone formation promoters often dominate osteoporosis treatment. Although conventional drugs can alleviate symptoms and reduce fracture risk, they often come with musculoskeletal, allergic and digestive side effects. Natural traditional Chinese medicine (TCM) products, known for their multi-targeting, high safety, efficacy and low cost, have been widely used in the treatment and prevention of osteoporosis in recent years and have gradually been recognised by many experts locally and abroad. This paper summarises recent research progress on natural TCM products in preventing and treating osteoporosis and provides a theoretical and experimental basis for the development of new drugs and the improvement of osteoporosis management. |
| format | Article |
| id | doaj-art-23af8a31e5b54cba9a00cbea509fe87a |
| institution | DOAJ |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-23af8a31e5b54cba9a00cbea509fe87a2025-08-20T03:10:30ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-05-0120112610.1186/s13018-025-05879-wNatural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosisBo Liu0Xue Mao1Zhe-Jian-Yi Gao2Huan Wang3Department of Orthopedics, The Fourth People’s Hospital of ShenyangDepartment of Orthopedics, Fushun Hospital of Chinese MedicineDepartment of Orthopedics, Fushun Hospital of Chinese MedicineDepartment of Orthopedics, Liaoning University of Traditional Chinese MedicineAbstract Osteoporosis is a systemic metabolic degenerative bone disease characterised by decreased bone mass, impaired bone microstructure, weakened bone strength and susceptibility to fracture. In China, the prevention and treatment of osteoporosis is faced with a high disease prevalence rate but low awareness, diagnosis and treatment rates. Bone resorption inhibitors and bone formation promoters often dominate osteoporosis treatment. Although conventional drugs can alleviate symptoms and reduce fracture risk, they often come with musculoskeletal, allergic and digestive side effects. Natural traditional Chinese medicine (TCM) products, known for their multi-targeting, high safety, efficacy and low cost, have been widely used in the treatment and prevention of osteoporosis in recent years and have gradually been recognised by many experts locally and abroad. This paper summarises recent research progress on natural TCM products in preventing and treating osteoporosis and provides a theoretical and experimental basis for the development of new drugs and the improvement of osteoporosis management.https://doi.org/10.1186/s13018-025-05879-wOsteoporosisOsteoblastOsteoclastNatural productsTraditional Chinese medicine |
| spellingShingle | Bo Liu Xue Mao Zhe-Jian-Yi Gao Huan Wang Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis Journal of Orthopaedic Surgery and Research Osteoporosis Osteoblast Osteoclast Natural products Traditional Chinese medicine |
| title | Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis |
| title_full | Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis |
| title_fullStr | Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis |
| title_full_unstemmed | Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis |
| title_short | Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis |
| title_sort | natural traditional chinese medicine products emerging therapeutic targets for the treatment of osteoporosis |
| topic | Osteoporosis Osteoblast Osteoclast Natural products Traditional Chinese medicine |
| url | https://doi.org/10.1186/s13018-025-05879-w |
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