Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases

Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases

Abstract Background This study investigates the causal role of metabolites mediating immune cells in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) through a Mendelian randomization (MR) study. Methods The two-sample and two-step MR methods were used for the current analysis: (1) causal e...

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Bibliographic Details
Main Authors: Jinpeng Wei, Jian Li, Tianyang Li, Tao Xu, Yingchi Zhang, Shuhan Yang, Hua Wu, Haihu Hao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Arthritis Research & Therapy
Subjects:
Autoimmune diseases
Mendelian randomization
Immune cells
Metabolites
Online Access:https://doi.org/10.1186/s13075-024-03445-z
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