Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering
The increasing applications of surface-enhanced Raman scattering (SERS) has led to the development of various SERS-active platforms (SERS substrates) for SERS measurement. This work reviews the current optimization techniques available for improving the performance of some of these SERS substrates....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2012/319038 |
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| _version_ | 1832565360666083328 |
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| author | Charles K. Klutse Adam Mayer Julia Wittkamper Brian M. Cullum |
| author_facet | Charles K. Klutse Adam Mayer Julia Wittkamper Brian M. Cullum |
| author_sort | Charles K. Klutse |
| collection | DOAJ |
| description | The increasing applications of surface-enhanced Raman scattering (SERS) has led to the development of various SERS-active platforms (SERS substrates) for SERS measurement. This work reviews the current optimization techniques available for improving the performance of some of these SERS substrates. The work particularly identifies self-assembled-monolayer- (SAM-) based substrate modification for optimum SERS activity and wider applications. An overview of SERS, SAM, and studies involving SAM-modified substrates is highlighted. The focus of the paper then shifts to the use of SAMs to improve analytical applications of SERS substrates by addressing issues including long-term stability, selectivity, reproducibility, and functionalization, and so forth. The paper elaborates on the use of SAMs to achieve optimum SERS enhancement. Specific examples are based on novel multilayered SERS substrates developed in the author’s laboratory where SAMs have been demonstrated as excellent dielectric spacers for improving SERS enhancement more than 20-fold relative to conventional single layer SERS substrates. Such substrate optimization can significantly improve the sensitivity of the SERS method for analyte detection. |
| format | Article |
| id | doaj-art-23a3579c49f644549787e9274cd39b36 |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-23a3579c49f644549787e9274cd39b362025-02-03T01:07:49ZengWileyJournal of Nanotechnology1687-95031687-95112012-01-01201210.1155/2012/319038319038Applications of Self-Assembled Monolayers in Surface-Enhanced Raman ScatteringCharles K. Klutse0Adam Mayer1Julia Wittkamper2Brian M. Cullum3Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USADepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USADepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USADepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USAThe increasing applications of surface-enhanced Raman scattering (SERS) has led to the development of various SERS-active platforms (SERS substrates) for SERS measurement. This work reviews the current optimization techniques available for improving the performance of some of these SERS substrates. The work particularly identifies self-assembled-monolayer- (SAM-) based substrate modification for optimum SERS activity and wider applications. An overview of SERS, SAM, and studies involving SAM-modified substrates is highlighted. The focus of the paper then shifts to the use of SAMs to improve analytical applications of SERS substrates by addressing issues including long-term stability, selectivity, reproducibility, and functionalization, and so forth. The paper elaborates on the use of SAMs to achieve optimum SERS enhancement. Specific examples are based on novel multilayered SERS substrates developed in the author’s laboratory where SAMs have been demonstrated as excellent dielectric spacers for improving SERS enhancement more than 20-fold relative to conventional single layer SERS substrates. Such substrate optimization can significantly improve the sensitivity of the SERS method for analyte detection.http://dx.doi.org/10.1155/2012/319038 |
| spellingShingle | Charles K. Klutse Adam Mayer Julia Wittkamper Brian M. Cullum Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering Journal of Nanotechnology |
| title | Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering |
| title_full | Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering |
| title_fullStr | Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering |
| title_full_unstemmed | Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering |
| title_short | Applications of Self-Assembled Monolayers in Surface-Enhanced Raman Scattering |
| title_sort | applications of self assembled monolayers in surface enhanced raman scattering |
| url | http://dx.doi.org/10.1155/2012/319038 |
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