Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population
Background. Homocysteine (Hcy) levels were higher in patients with Parkinson’s disease (PD). This could be partially explained by levodopa treatment. Whether untreated PD patients have higher Hcy levels is contradictory. Methods. A community-based study was conducted using a two-stage approach for s...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/9539836 |
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| _version_ | 1849306750610571264 |
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| author | Zhang Wei Wang Tiandong Li Yang Meng Huaxing Min Guowen Fang Yalan Niu Xiaoyuan |
| author_facet | Zhang Wei Wang Tiandong Li Yang Meng Huaxing Min Guowen Fang Yalan Niu Xiaoyuan |
| author_sort | Zhang Wei |
| collection | DOAJ |
| description | Background. Homocysteine (Hcy) levels were higher in patients with Parkinson’s disease (PD). This could be partially explained by levodopa treatment. Whether untreated PD patients have higher Hcy levels is contradictory. Methods. A community-based study was conducted using a two-stage approach for subjects ≥ 55 years to find PD patients in 3 towns of Lüliang City. Blood samples were collected. Serum Hcy, folate, and vitamin B12 concentrations were measured. For each untreated PD patient, 5 controls were selected matched with age and sex to evaluate the relationship between Hcy levels and PD. Results. Of 6338 eligible residents, 72.7% participated in the study. 31 PD cases were identified. The crude prevalence of PD for people ≥ 55 years was 0.67%. Blood samples were collected from 1845 subjects, including 17 untreated PD patients. There was no difference for concentrations of serum Hcy, folate, and vitamin B12 between cases and controls (P>0.05). In univariate and multivariate analysis, there was significant inverse relation between PD and current smoking (P<0.05). No other factor was significant statistically. Conclusions. The prevalence of PD was comparable to earlier studies in China. Hyperhomocysteinemia was not a risk factor of PD, as well as folate and vitamin B12 deficiency. |
| format | Article |
| id | doaj-art-239ecb0d04314d1383d062db68306d77 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-239ecb0d04314d1383d062db68306d772025-08-20T03:54:57ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/95398369539836Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient PopulationZhang Wei0Wang Tiandong1Li Yang2Meng Huaxing3Min Guowen4Fang Yalan5Niu Xiaoyuan6Department of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaDepartment of Neurology, First Hospital, Shanxi Medical University, No. 85, Jiefang Nan Street, Yingze District, Taiyuan 030000, ChinaBackground. Homocysteine (Hcy) levels were higher in patients with Parkinson’s disease (PD). This could be partially explained by levodopa treatment. Whether untreated PD patients have higher Hcy levels is contradictory. Methods. A community-based study was conducted using a two-stage approach for subjects ≥ 55 years to find PD patients in 3 towns of Lüliang City. Blood samples were collected. Serum Hcy, folate, and vitamin B12 concentrations were measured. For each untreated PD patient, 5 controls were selected matched with age and sex to evaluate the relationship between Hcy levels and PD. Results. Of 6338 eligible residents, 72.7% participated in the study. 31 PD cases were identified. The crude prevalence of PD for people ≥ 55 years was 0.67%. Blood samples were collected from 1845 subjects, including 17 untreated PD patients. There was no difference for concentrations of serum Hcy, folate, and vitamin B12 between cases and controls (P>0.05). In univariate and multivariate analysis, there was significant inverse relation between PD and current smoking (P<0.05). No other factor was significant statistically. Conclusions. The prevalence of PD was comparable to earlier studies in China. Hyperhomocysteinemia was not a risk factor of PD, as well as folate and vitamin B12 deficiency.http://dx.doi.org/10.1155/2016/9539836 |
| spellingShingle | Zhang Wei Wang Tiandong Li Yang Meng Huaxing Min Guowen Fang Yalan Niu Xiaoyuan Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population Parkinson's Disease |
| title | Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population |
| title_full | Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population |
| title_fullStr | Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population |
| title_full_unstemmed | Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population |
| title_short | Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population |
| title_sort | parkinson s disease and homocysteine a community based study in a folate and vitamin b12 deficient population |
| url | http://dx.doi.org/10.1155/2016/9539836 |
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