Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome
Jiayi Chen,* Zixiang Pang,* Chengyu Qin, Zuhai Huang, Yuanming Chen Department of Spinal Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespon...
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Dove Medical Press
2025-07-01
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| Series: | Infection and Drug Resistance |
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| author | Chen J Pang Z Qin C Huang Z Chen Y |
| author_facet | Chen J Pang Z Qin C Huang Z Chen Y |
| author_sort | Chen J |
| collection | DOAJ |
| description | Jiayi Chen,* Zixiang Pang,* Chengyu Qin, Zuhai Huang, Yuanming Chen Department of Spinal Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuanming Chen, Department of Spinal Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China, Email rkyygk@163.comIntroduction: Talaromycosis is an opportunistic fungal disease caused by Talaromyces marneffei (TM), a significant pathogen predominantly affecting immunocompromised individuals, especially those with HIV infection. Although traditionally regarded as an HIV-associated infection, increasing cases have been reported among HIV-negative patients.Case Presentation: This report details a case of a 36-year-old HIV-negative woman infected with Talaromyces marneffei. The patient presented with bone destruction and was diagnosed through metagenomic next-generation sequencing (mNGS). Despite receiving antifungal, anti-inflammatory, and symptomatic treatment, the infection remained uncontrolled, ultimately progressing to multi-organ failure and resulting in death.Conclusion: Bone damage due to Talaromyces marneffei infection is very uncommon in HIV-negative patients. Thus, healthcare providers should be alert for possible skeletal lesions linked to this infection. Early diagnosis and appropriate antimicrobial treatment are vital for the patient’s prognosis.Keywords: Talaromyces marneffei, HIV-negative, bone destruction, metagenomic next-generation sequencing, antifungal treatment |
| format | Article |
| id | doaj-art-239ea071018d4862ae624ee78e82e63b |
| institution | OA Journals |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-239ea071018d4862ae624ee78e82e63b2025-08-20T02:37:09ZengDove Medical PressInfection and Drug Resistance1178-69732025-07-01Volume 18Issue 134813486104728Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal OutcomeChen J0Pang Z1Qin C2Huang Z3Chen Y4Department of Spinal OrthopedicsDepartment of Spinal OrthopedicsDepartment of Spinal OrthopedicsDepartment of Spinal OrthopedicsDepartment of Spinal OrthopedicsJiayi Chen,* Zixiang Pang,* Chengyu Qin, Zuhai Huang, Yuanming Chen Department of Spinal Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuanming Chen, Department of Spinal Orthopedics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China, Email rkyygk@163.comIntroduction: Talaromycosis is an opportunistic fungal disease caused by Talaromyces marneffei (TM), a significant pathogen predominantly affecting immunocompromised individuals, especially those with HIV infection. Although traditionally regarded as an HIV-associated infection, increasing cases have been reported among HIV-negative patients.Case Presentation: This report details a case of a 36-year-old HIV-negative woman infected with Talaromyces marneffei. The patient presented with bone destruction and was diagnosed through metagenomic next-generation sequencing (mNGS). Despite receiving antifungal, anti-inflammatory, and symptomatic treatment, the infection remained uncontrolled, ultimately progressing to multi-organ failure and resulting in death.Conclusion: Bone damage due to Talaromyces marneffei infection is very uncommon in HIV-negative patients. Thus, healthcare providers should be alert for possible skeletal lesions linked to this infection. Early diagnosis and appropriate antimicrobial treatment are vital for the patient’s prognosis.Keywords: Talaromyces marneffei, HIV-negative, bone destruction, metagenomic next-generation sequencing, antifungal treatmenthttps://www.dovepress.com/metagenomic-next-generation-sequencing-unravels-talaromyces-marneffei--peer-reviewed-fulltext-article-IDRTalaromyces MarneffeiHIV-negativeBone DestructionMetagenomic Next-Generation SequencingAntifungal Treatment |
| spellingShingle | Chen J Pang Z Qin C Huang Z Chen Y Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome Infection and Drug Resistance Talaromyces Marneffei HIV-negative Bone Destruction Metagenomic Next-Generation Sequencing Antifungal Treatment |
| title | Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome |
| title_full | Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome |
| title_fullStr | Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome |
| title_full_unstemmed | Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome |
| title_short | Metagenomic Next-Generation Sequencing Unravels Talaromyces Marneffei-Induced Bone Destruction in an HIV-Negative Woman: A Case Report with Fatal Outcome |
| title_sort | metagenomic next generation sequencing unravels talaromyces marneffei induced bone destruction in an hiv negative woman a case report with fatal outcome |
| topic | Talaromyces Marneffei HIV-negative Bone Destruction Metagenomic Next-Generation Sequencing Antifungal Treatment |
| url | https://www.dovepress.com/metagenomic-next-generation-sequencing-unravels-talaromyces-marneffei--peer-reviewed-fulltext-article-IDR |
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