Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications
Magnesium (Mg) alloys with biodegradability and excellent mechanical properties are in high demand for applications in guided bone regeneration (GBR). However, the clinical application of Mg alloys is hindered by infection risks and limited osteogenesis. Herein, a structure-functional integrated Mg-...
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KeAi Communications Co., Ltd.
2025-02-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724000562 |
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| author | Yanbo Shan Bo Qiao Sihui Ouyang Chengao Du Lisheng Zhao Gang Wang Jianting Ye Yingjie Xiong Yu Wei Jiangfeng Song Jia She Jiang Peng Xianhua Chen Fusheng Pan Ning Wen |
| author_facet | Yanbo Shan Bo Qiao Sihui Ouyang Chengao Du Lisheng Zhao Gang Wang Jianting Ye Yingjie Xiong Yu Wei Jiangfeng Song Jia She Jiang Peng Xianhua Chen Fusheng Pan Ning Wen |
| author_sort | Yanbo Shan |
| collection | DOAJ |
| description | Magnesium (Mg) alloys with biodegradability and excellent mechanical properties are in high demand for applications in guided bone regeneration (GBR). However, the clinical application of Mg alloys is hindered by infection risks and limited osteogenesis. Herein, a structure-functional integrated Mg-Ca/Mg-Cu bilayer membrane was rolled at 150 °C through various single-pass reductions by using online heating rolling. The Mg-Cu layer was specifically engineered to exhibit antibacterial properties tailored for gingival tissue, while the Mg-Ca layer was designed to support bone regeneration within the defect cavity. The bilayer membrane demonstrated a flexural yield strength of 421.0 MPa and a modulus of 58.6 GPa, indicating exceptional deformation resistance. Furthermore, it maintained notable structural stability by retaining 86.4% of its volume after 21 days in Hanks' solution. In vitro results revealed that the bilayer membrane exhibited favorable biocompatibility and promoted osteogenesis via the synergetic effect of released Mg2+ and Ca2+ ions. The rapid release of Cu2+ ions and the creation of an alkaline environment further improved antibacterial properties, potentially preventing postoperative infections. Additionally, in an in vivo rat calvarial defect model, the membrane demonstrated its capability to stimulate new bone formation. In summary, the Mg-Ca/Mg-Cu bilayer membrane exhibited outstanding mechanical stability, favorable corrosion rates, extraordinary osteogenic and antibacterial activity simultaneously. Consequently, it holds promise as a robust barrier membrane in GBR applications. |
| format | Article |
| id | doaj-art-239e2fb3a7ef4533b2bf72c32b5013c5 |
| institution | DOAJ |
| issn | 2213-9567 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-239e2fb3a7ef4533b2bf72c32b5013c52025-08-20T03:02:06ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672025-02-0113279280910.1016/j.jma.2024.01.034Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applicationsYanbo Shan0Bo Qiao1Sihui Ouyang2Chengao Du3Lisheng Zhao4Gang Wang5Jianting Ye6Yingjie Xiong7Yu Wei8Jiangfeng Song9Jia She10Jiang Peng11Xianhua Chen12Fusheng Pan13Ning Wen14Chinese PLA Medical School, Beijing 100853, PR China; Institute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China; Key Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, PLA, Beijing 100853, PR ChinaInstitute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing 400044, PR China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing 400044, PR China; Corresponding authors at: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China.College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR ChinaInstitute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR ChinaInstitute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR ChinaKey Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, PLA, Beijing 100853, PR ChinaKey Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, PLA, Beijing 100853, PR ChinaKey Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, PLA, Beijing 100853, PR ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing 400044, PR China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing 400044, PR ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing 400044, PR China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing 400044, PR China; Corresponding authors at: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China.Key Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, PLA, Beijing 100853, PR ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing 400044, PR China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing 400044, PR ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing 400044, PR China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing 400044, PR ChinaInstitute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China; Corresponding author at: Institute of Stomatology, Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, PR China.Magnesium (Mg) alloys with biodegradability and excellent mechanical properties are in high demand for applications in guided bone regeneration (GBR). However, the clinical application of Mg alloys is hindered by infection risks and limited osteogenesis. Herein, a structure-functional integrated Mg-Ca/Mg-Cu bilayer membrane was rolled at 150 °C through various single-pass reductions by using online heating rolling. The Mg-Cu layer was specifically engineered to exhibit antibacterial properties tailored for gingival tissue, while the Mg-Ca layer was designed to support bone regeneration within the defect cavity. The bilayer membrane demonstrated a flexural yield strength of 421.0 MPa and a modulus of 58.6 GPa, indicating exceptional deformation resistance. Furthermore, it maintained notable structural stability by retaining 86.4% of its volume after 21 days in Hanks' solution. In vitro results revealed that the bilayer membrane exhibited favorable biocompatibility and promoted osteogenesis via the synergetic effect of released Mg2+ and Ca2+ ions. The rapid release of Cu2+ ions and the creation of an alkaline environment further improved antibacterial properties, potentially preventing postoperative infections. Additionally, in an in vivo rat calvarial defect model, the membrane demonstrated its capability to stimulate new bone formation. In summary, the Mg-Ca/Mg-Cu bilayer membrane exhibited outstanding mechanical stability, favorable corrosion rates, extraordinary osteogenic and antibacterial activity simultaneously. Consequently, it holds promise as a robust barrier membrane in GBR applications.http://www.sciencedirect.com/science/article/pii/S2213956724000562BiodegradabilityMagnesium alloyGuided bone regeneration membraneOsteogenesisAntibacterial |
| spellingShingle | Yanbo Shan Bo Qiao Sihui Ouyang Chengao Du Lisheng Zhao Gang Wang Jianting Ye Yingjie Xiong Yu Wei Jiangfeng Song Jia She Jiang Peng Xianhua Chen Fusheng Pan Ning Wen Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications Journal of Magnesium and Alloys Biodegradability Magnesium alloy Guided bone regeneration membrane Osteogenesis Antibacterial |
| title | Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications |
| title_full | Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications |
| title_fullStr | Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications |
| title_full_unstemmed | Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications |
| title_short | Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications |
| title_sort | biodegradable mg ca mg cu bilayer membranes with enhanced mechanical osteogenesis and antibacterial performances for gbr applications |
| topic | Biodegradability Magnesium alloy Guided bone regeneration membrane Osteogenesis Antibacterial |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724000562 |
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