The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis
Background: The management of OSMF aims to alleviate the signs and symptoms, such as burning sensation and release of the fibrotic bands to assist oral opening. Surgical excision of the fibrotic bands is the best choice in the treatment of advanced OSMF. Interpositional grafts are used to cover the...
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EDP Sciences
2025-01-01
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| Series: | Journal of Oral Medicine and Oral Surgery |
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| Online Access: | https://www.jomos.org/articles/mbcb/full_html/2025/01/mbcb240189/mbcb240189.html |
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| author | Manekar Varsha Sunil Kataria Mehak Shetty Priyanka Pandilwar Prashant Datarkar Abhay |
| author_facet | Manekar Varsha Sunil Kataria Mehak Shetty Priyanka Pandilwar Prashant Datarkar Abhay |
| author_sort | Manekar Varsha Sunil |
| collection | DOAJ |
| description | Background: The management of OSMF aims to alleviate the signs and symptoms, such as burning sensation and release of the fibrotic bands to assist oral opening. Surgical excision of the fibrotic bands is the best choice in the treatment of advanced OSMF. Interpositional grafts are used to cover the raw surgical defects following the fibrotic bands' excision. They can be local (tongue flap, palatal island flap, buccal fat pad, nasolabial flap, and temporalis fascia flap) or distant (abdominal dermal fat graft, anterolateral thigh flap). This systematic review was conducted to evaluate which type of interpositional graft is effective in the surgical management of advanced oral submucous fibrosis. Material and method: A Literature search was performed in 12 electronic databases for articles published between 2000, and August 31, 2023. Two reviewers independently reviewed the articles. Ten articles (Non randomized controlled trial (NRCT)-5 and randomized controlled trial (RCT)-5) were selected based on the inclusion criteria. For NRCTs, Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies and ROB b tool for RCT were used to evaluate the risk of bias. Results: Ten studies were selected based on the inclusion and exclusion criteria. It included; 5 NRCTs and 5 RCTs. Meta-analysis was performed, and the mouth opening was greater in subjects treated with nasolabial flap than other flap designs at sixth month and 12th month follow up. However, the difference between the two groups was statistically non-significant (p = 0.19). The Buccal Fat pad flap also shows successful results but not statistically significant. Conclusion: The observations of this review can help enhance awareness among the healthcare professionals, and clinicians about recommending nasolabial flap as an interpositional graft in advanced OSMF cases making the best use of its advantages. |
| format | Article |
| id | doaj-art-239cf476779a4f289722c19b6daeb682 |
| institution | DOAJ |
| issn | 2608-1326 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Journal of Oral Medicine and Oral Surgery |
| spelling | doaj-art-239cf476779a4f289722c19b6daeb6822025-08-20T03:07:24ZengEDP SciencesJournal of Oral Medicine and Oral Surgery2608-13262025-01-01311910.1051/mbcb/2025003mbcb240189The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysisManekar Varsha Sunil0https://orcid.org/0000-0002-7019-8329Kataria Mehak1https://orcid.org/0009-0008-5168-5640Shetty Priyanka2https://orcid.org/0000-0001-8048-4022Pandilwar Prashant3Datarkar Abhay4Department of Oral and Maxillofacial Surgery, Government Dental College and HospitalDepartment of Oral and Maxillofacial Surgery, Government Dental College and HospitalDepartment of Oral and Maxillofacial Surgery, Government Dental College and HospitalDepartment of Oral and Maxillofacial Surgery, Government Dental College and HospitalDean, Government Dental College and HospitalBackground: The management of OSMF aims to alleviate the signs and symptoms, such as burning sensation and release of the fibrotic bands to assist oral opening. Surgical excision of the fibrotic bands is the best choice in the treatment of advanced OSMF. Interpositional grafts are used to cover the raw surgical defects following the fibrotic bands' excision. They can be local (tongue flap, palatal island flap, buccal fat pad, nasolabial flap, and temporalis fascia flap) or distant (abdominal dermal fat graft, anterolateral thigh flap). This systematic review was conducted to evaluate which type of interpositional graft is effective in the surgical management of advanced oral submucous fibrosis. Material and method: A Literature search was performed in 12 electronic databases for articles published between 2000, and August 31, 2023. Two reviewers independently reviewed the articles. Ten articles (Non randomized controlled trial (NRCT)-5 and randomized controlled trial (RCT)-5) were selected based on the inclusion criteria. For NRCTs, Joanna Briggs Institute Critical Appraisal Checklist for Quasi-Experimental Studies and ROB b tool for RCT were used to evaluate the risk of bias. Results: Ten studies were selected based on the inclusion and exclusion criteria. It included; 5 NRCTs and 5 RCTs. Meta-analysis was performed, and the mouth opening was greater in subjects treated with nasolabial flap than other flap designs at sixth month and 12th month follow up. However, the difference between the two groups was statistically non-significant (p = 0.19). The Buccal Fat pad flap also shows successful results but not statistically significant. Conclusion: The observations of this review can help enhance awareness among the healthcare professionals, and clinicians about recommending nasolabial flap as an interpositional graft in advanced OSMF cases making the best use of its advantages.https://www.jomos.org/articles/mbcb/full_html/2025/01/mbcb240189/mbcb240189.htmlosmforal submucous fibrosisinterpositional flaps |
| spellingShingle | Manekar Varsha Sunil Kataria Mehak Shetty Priyanka Pandilwar Prashant Datarkar Abhay The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis Journal of Oral Medicine and Oral Surgery osmf oral submucous fibrosis interpositional flaps |
| title | The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis |
| title_full | The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis |
| title_fullStr | The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis |
| title_full_unstemmed | The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis |
| title_short | The effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis (OSMF): a systematic review with meta-analysis |
| title_sort | effectiveness of interpositional grafts in surgical management of advanced oral submucous fibrosis osmf a systematic review with meta analysis |
| topic | osmf oral submucous fibrosis interpositional flaps |
| url | https://www.jomos.org/articles/mbcb/full_html/2025/01/mbcb240189/mbcb240189.html |
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