Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment
Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only proven treatment strategy for glaucoma. However, some patients show progressive loss of visual field and quality of life d...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/6138132 |
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| author | Barbara Cvenkel Miriam Kolko |
| author_facet | Barbara Cvenkel Miriam Kolko |
| author_sort | Barbara Cvenkel |
| collection | DOAJ |
| description | Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only proven treatment strategy for glaucoma. However, some patients show progressive loss of visual field and quality of life despite controlled IOP which indicates that other factors are implicated in glaucoma. Therefore, approaches that could prevent or decrease the rate of progression and do not rely on IOP lowering have gained much attention. Effective neuroprotection has been reported in animal models of glaucoma, but till now, no neuroprotective agents have been clinically approved. The present update provides an overview of currently available IOP-lowering medications. Moreover, potential new treatment targets for IOP-lowering and neuroprotective therapy are discussed. Finally, future trends in glaucoma therapy are addressed, including sustained drug delivery systems and progress toward personalized medicine. |
| format | Article |
| id | doaj-art-239a668a5d734c5d83d0668e51ca39b1 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-239a668a5d734c5d83d0668e51ca39b12025-08-20T02:04:15ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/61381326138132Current Medical Therapy and Future Trends in the Management of Glaucoma TreatmentBarbara Cvenkel0Miriam Kolko1Department of Ophthalmology, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkGlaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only proven treatment strategy for glaucoma. However, some patients show progressive loss of visual field and quality of life despite controlled IOP which indicates that other factors are implicated in glaucoma. Therefore, approaches that could prevent or decrease the rate of progression and do not rely on IOP lowering have gained much attention. Effective neuroprotection has been reported in animal models of glaucoma, but till now, no neuroprotective agents have been clinically approved. The present update provides an overview of currently available IOP-lowering medications. Moreover, potential new treatment targets for IOP-lowering and neuroprotective therapy are discussed. Finally, future trends in glaucoma therapy are addressed, including sustained drug delivery systems and progress toward personalized medicine.http://dx.doi.org/10.1155/2020/6138132 |
| spellingShingle | Barbara Cvenkel Miriam Kolko Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment Journal of Ophthalmology |
| title | Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment |
| title_full | Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment |
| title_fullStr | Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment |
| title_full_unstemmed | Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment |
| title_short | Current Medical Therapy and Future Trends in the Management of Glaucoma Treatment |
| title_sort | current medical therapy and future trends in the management of glaucoma treatment |
| url | http://dx.doi.org/10.1155/2020/6138132 |
| work_keys_str_mv | AT barbaracvenkel currentmedicaltherapyandfuturetrendsinthemanagementofglaucomatreatment AT miriamkolko currentmedicaltherapyandfuturetrendsinthemanagementofglaucomatreatment |