Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia
Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to aberrantly expressed markers and minimizing e...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/7456378 |
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| author | William A. Hammond Pooja Advani Rhett P. Ketterling Daniel Van Dyke James M. Foran Liuyan Jiang |
| author_facet | William A. Hammond Pooja Advani Rhett P. Ketterling Daniel Van Dyke James M. Foran Liuyan Jiang |
| author_sort | William A. Hammond |
| collection | DOAJ |
| description | Updated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to aberrantly expressed markers and minimizing expression of myeloid markers other than myeloperoxidase (MPO), potentially foregoing consolidative allogeneic transplant for an otherwise “favorable” lymphoid phenotypic leukemia. We present a case of MPO-negative, myeloid antigen-positive acute lymphoblastic leukemia who progressed with refractory phenotypic acute myeloid leukemia while receiving lymphoid-directed therapy and discuss concerns raised by the adoption of the new, more stringent diagnostic criteria for BAL. |
| format | Article |
| id | doaj-art-23995debc8a248129a8fcd32a98a821d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-23995debc8a248129a8fcd32a98a821d2025-02-03T05:44:49ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/74563787456378Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute LeukemiaWilliam A. Hammond0Pooja Advani1Rhett P. Ketterling2Daniel Van Dyke3James M. Foran4Liuyan Jiang5Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USADivision of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USADivision of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADivision of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADivision of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USADivision of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USAUpdated WHO criteria define mixed phenotype acute leukemia (MPAL) with more stringent diagnostic criteria than the formerly described entity biphenotypic acute leukemia (BAL). The changes in diagnostic criteria influence management by assigning weight to aberrantly expressed markers and minimizing expression of myeloid markers other than myeloperoxidase (MPO), potentially foregoing consolidative allogeneic transplant for an otherwise “favorable” lymphoid phenotypic leukemia. We present a case of MPO-negative, myeloid antigen-positive acute lymphoblastic leukemia who progressed with refractory phenotypic acute myeloid leukemia while receiving lymphoid-directed therapy and discuss concerns raised by the adoption of the new, more stringent diagnostic criteria for BAL.http://dx.doi.org/10.1155/2018/7456378 |
| spellingShingle | William A. Hammond Pooja Advani Rhett P. Ketterling Daniel Van Dyke James M. Foran Liuyan Jiang Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia Case Reports in Hematology |
| title | Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia |
| title_full | Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia |
| title_fullStr | Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia |
| title_full_unstemmed | Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia |
| title_short | Biphenotypic Acute Leukemia versus Myeloid Antigen-Positive ALL: Clinical Relevance of WHO Criteria for Mixed Phenotype Acute Leukemia |
| title_sort | biphenotypic acute leukemia versus myeloid antigen positive all clinical relevance of who criteria for mixed phenotype acute leukemia |
| url | http://dx.doi.org/10.1155/2018/7456378 |
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