Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection
<b>Background/Objectives:</b> The coronavirus disease (COVID-19) pandemic was associated with an intense impact on health worldwide. Among the sequelae, it became necessary to clarify respiratory impairment related to lung function and aerobic capacity, as well as the treatment of curati...
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MDPI AG
2025-04-01
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| author | Emilia Raposo Nascimento Paloma Lopes Francisco Parazzi Fernando Augusto Lima Marson Maria Ângela Gonçalves Oliveira Ribeiro Carla Cristina Sousa Gomez Patrícia Blau Margosian Conti Bianca Aparecida Siqueira Edvane Aparecida Braz Araújo Silva José Dirceu Ribeiro |
| author_facet | Emilia Raposo Nascimento Paloma Lopes Francisco Parazzi Fernando Augusto Lima Marson Maria Ângela Gonçalves Oliveira Ribeiro Carla Cristina Sousa Gomez Patrícia Blau Margosian Conti Bianca Aparecida Siqueira Edvane Aparecida Braz Araújo Silva José Dirceu Ribeiro |
| author_sort | Emilia Raposo Nascimento |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The coronavirus disease (COVID-19) pandemic was associated with an intense impact on health worldwide. Among the sequelae, it became necessary to clarify respiratory impairment related to lung function and aerobic capacity, as well as the treatment of curative and preventive measures of pulmonary involvement. In this context, this study aimed to compare vital signs, the sensation of dyspnea (Borg scale), lung function, and exercise tolerance before and after the use of non-invasive mechanical ventilation (NIV) in adults of both sexes after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). <b>Methods:</b> A cross-sectional analytical clinical study was performed with the inclusion of individuals who had been diagnosed with COVID-19 at least three months before data collection. Individuals were evaluated for vital signs (heart rate and peripheral oxygen saturation), Borg scale, spirometry, and submaximal exercise protocol of two minutes of the step test before and after receiving NIV in ventilation mode by continuous positive airway pressure of 6 cm H<sub>2</sub>O for 30 min. <b>Results:</b> A total of 50 participants were enrolled and grouped as a mild (N = 25) or severe (N = 25) clinical phenotype during SARS-CoV-2 infection according to the criteria of the World Health Organization. In our data, the forced vital capacity (<i>p</i> < 0.001), the ratio between the forced expiratory volume in the first one second to the forced vital capacity and the forced vital capacity (<i>p</i> = 0.020), and the two-minute submaximal step exercise protocol (number of steps—<i>p</i> = 0.001) showed a statistical improvement in the severe clinical phenotype group after NIV. In addition, forced expiratory volume in the first one second to the forced vital capacity (<i>p</i> = 0.032) and the two-minute submaximal step exercise protocol (number of steps—<i>p</i> < 0.001) showed a statistical improvement in the mild clinical phenotype group after NIV. No changes were described for vital signs and the Borg scale. <b>Conclusions:</b> This study allowed us to identify that NIV is a tool that promotes better exercise capacity by increasing the number of steps achieved in both clinical phenotype groups and improving lung function observed in the spirometry markers. |
| format | Article |
| id | doaj-art-23994372f95e465fab91382ee025a78d |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-04-01 |
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| series | Clinics and Practice |
| spelling | doaj-art-23994372f95e465fab91382ee025a78d2025-08-20T02:24:45ZengMDPI AGClinics and Practice2039-72832025-04-011547310.3390/clinpract15040073Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 InfectionEmilia Raposo Nascimento0Paloma Lopes Francisco Parazzi1Fernando Augusto Lima Marson2Maria Ângela Gonçalves Oliveira Ribeiro3Carla Cristina Sousa Gomez4Patrícia Blau Margosian Conti5Bianca Aparecida Siqueira6Edvane Aparecida Braz Araújo Silva7José Dirceu Ribeiro8Center for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, BrazilLaboratory of Molecular Biology and Genetics, Laboratory of Clinical and Molecular Microbiology, LunGuardian Research Group—Epidemiology of Respiratory and Infectious Diseases, Postgraduate Program in Health Science, São Francisco University, Bragança Paulista 12916-900, SP, BrazilCollaborating Physiotherapist, São João da Boa Vista 13876-750, SP, BrazilCenter for Research in Pediatrics, University of Campinas, Campinas 13083-871, SP, Brazil<b>Background/Objectives:</b> The coronavirus disease (COVID-19) pandemic was associated with an intense impact on health worldwide. Among the sequelae, it became necessary to clarify respiratory impairment related to lung function and aerobic capacity, as well as the treatment of curative and preventive measures of pulmonary involvement. In this context, this study aimed to compare vital signs, the sensation of dyspnea (Borg scale), lung function, and exercise tolerance before and after the use of non-invasive mechanical ventilation (NIV) in adults of both sexes after acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). <b>Methods:</b> A cross-sectional analytical clinical study was performed with the inclusion of individuals who had been diagnosed with COVID-19 at least three months before data collection. Individuals were evaluated for vital signs (heart rate and peripheral oxygen saturation), Borg scale, spirometry, and submaximal exercise protocol of two minutes of the step test before and after receiving NIV in ventilation mode by continuous positive airway pressure of 6 cm H<sub>2</sub>O for 30 min. <b>Results:</b> A total of 50 participants were enrolled and grouped as a mild (N = 25) or severe (N = 25) clinical phenotype during SARS-CoV-2 infection according to the criteria of the World Health Organization. In our data, the forced vital capacity (<i>p</i> < 0.001), the ratio between the forced expiratory volume in the first one second to the forced vital capacity and the forced vital capacity (<i>p</i> = 0.020), and the two-minute submaximal step exercise protocol (number of steps—<i>p</i> = 0.001) showed a statistical improvement in the severe clinical phenotype group after NIV. In addition, forced expiratory volume in the first one second to the forced vital capacity (<i>p</i> = 0.032) and the two-minute submaximal step exercise protocol (number of steps—<i>p</i> < 0.001) showed a statistical improvement in the mild clinical phenotype group after NIV. No changes were described for vital signs and the Borg scale. <b>Conclusions:</b> This study allowed us to identify that NIV is a tool that promotes better exercise capacity by increasing the number of steps achieved in both clinical phenotype groups and improving lung function observed in the spirometry markers.https://www.mdpi.com/2039-7283/15/4/73Borg scalecoronavirus disease (COVID-19)heart ratenon-invasive ventilationpandemicperipheral oxygen saturation |
| spellingShingle | Emilia Raposo Nascimento Paloma Lopes Francisco Parazzi Fernando Augusto Lima Marson Maria Ângela Gonçalves Oliveira Ribeiro Carla Cristina Sousa Gomez Patrícia Blau Margosian Conti Bianca Aparecida Siqueira Edvane Aparecida Braz Araújo Silva José Dirceu Ribeiro Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection Clinics and Practice Borg scale coronavirus disease (COVID-19) heart rate non-invasive ventilation pandemic peripheral oxygen saturation |
| title | Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection |
| title_full | Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection |
| title_fullStr | Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection |
| title_full_unstemmed | Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection |
| title_short | Effect of Continuous Positive Airway Pressure (CPAP) Mode on Lung Function, Exercise Tolerance, Vital Signs, and Dyspnea After Acute SARS-CoV-2 Infection |
| title_sort | effect of continuous positive airway pressure cpap mode on lung function exercise tolerance vital signs and dyspnea after acute sars cov 2 infection |
| topic | Borg scale coronavirus disease (COVID-19) heart rate non-invasive ventilation pandemic peripheral oxygen saturation |
| url | https://www.mdpi.com/2039-7283/15/4/73 |
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