A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

Abstract Background A pathogenetic factor of ischemic stroke (IS) is oxidative stress. As a rate-limiting enzyme constituent in the glutathione synthetic pathway, the glutamate-cysteine ligase catalytic subunit (GCLC) exerts a crucial effect on the redox homeostasis. Several studies have shown that...

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Bibliographic Details
Main Authors: Tao Liao, Yin-Hua Weng, Jiang He, Mei-Rong Chen, Yu Chen, Zhong-Quan Qi, Zheng-Mian Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Ischemic stroke
GCLC
Single nucleotide polymorphism
Homocysteine
Susceptibility
Online Access:https://doi.org/10.1186/s40001-025-02688-z
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