Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age
Background: Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there ar...
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Elsevier
2021-03-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957220302229 |
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| author | Seh Hyun Kim Yoo-Jin Kim Seung Hyun Shin Hannah Cho Seung Han Shin Ee-Kyung Kim Han-Suk Kim Subeen Hong Seung Mi Lee |
| author_facet | Seh Hyun Kim Yoo-Jin Kim Seung Hyun Shin Hannah Cho Seung Han Shin Ee-Kyung Kim Han-Suk Kim Subeen Hong Seung Mi Lee |
| author_sort | Seh Hyun Kim |
| collection | DOAJ |
| description | Background: Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there are concerns regarding the effects of antenatal magnesium sulfate on neonates, especially regarding gastrointestinal morbidities. This study aims to explore the effects of antenatal magnesium sulfate on intestinal morbidities requiring surgery in preterm infants. Methods: This was a retrospective cohort study of 181 preterm infants who were born at less than 28 weeks of gestational age. Subjects were categorized as infants exposed to antenatal magnesium sulfate and those not exposed to antenatal magnesium sulfate. Results: Antenatal magnesium sulfate was associated with a decreased risk of surgical conditions of the intestine (OR 0.393, 95% CI 0.170–0.905). The multivariate analysis showed that the duration of antenatal magnesium sulfate use was associated with surgical conditions of the intestine (adjusted OR 0.766, 95% CI 0.589–0.997). In the <26 weeks of gestational age subgroup, the use of antenatal magnesium sulfate was significantly associated with decreased intestinal morbidities requiring surgery (adjusted OR 0.234, 95% CI 0.060–0.922). Conclusion: Antenatal magnesium sulfate use appears to have a protective effect on intestinal morbidities requiring surgery in preterm infants in a duration-dependent manner. Association of antenatal magnesium sulfate use and decreased intestinal morbidities requiring surgery was more distinct in preterm infants <26 weeks of gestational age. |
| format | Article |
| id | doaj-art-238e26ccc70e4f20bc2dabe29c67e0f8 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-238e26ccc70e4f20bc2dabe29c67e0f82025-08-20T03:17:51ZengElsevierPediatrics and Neonatology1875-95722021-03-0162220220710.1016/j.pedneo.2020.12.009Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational ageSeh Hyun Kim0Yoo-Jin Kim1Seung Hyun Shin2Hannah Cho3Seung Han Shin4Ee-Kyung Kim5Han-Suk Kim6Subeen Hong7Seung Mi Lee8Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of Korea; Corresponding author. Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of Korea. Fax: +82 2 2072 0509.Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul 03080, Republic of KoreaBackground: Antenatal magnesium sulfate is widely used as a tocolytic, for maternal seizures, and for seizure prophylaxis in preeclampsia. Recent studies have suggested that antenatal magnesium sulfate use is associated with favorable neurodevelopmental outcomes in preterm infants. However, there are concerns regarding the effects of antenatal magnesium sulfate on neonates, especially regarding gastrointestinal morbidities. This study aims to explore the effects of antenatal magnesium sulfate on intestinal morbidities requiring surgery in preterm infants. Methods: This was a retrospective cohort study of 181 preterm infants who were born at less than 28 weeks of gestational age. Subjects were categorized as infants exposed to antenatal magnesium sulfate and those not exposed to antenatal magnesium sulfate. Results: Antenatal magnesium sulfate was associated with a decreased risk of surgical conditions of the intestine (OR 0.393, 95% CI 0.170–0.905). The multivariate analysis showed that the duration of antenatal magnesium sulfate use was associated with surgical conditions of the intestine (adjusted OR 0.766, 95% CI 0.589–0.997). In the <26 weeks of gestational age subgroup, the use of antenatal magnesium sulfate was significantly associated with decreased intestinal morbidities requiring surgery (adjusted OR 0.234, 95% CI 0.060–0.922). Conclusion: Antenatal magnesium sulfate use appears to have a protective effect on intestinal morbidities requiring surgery in preterm infants in a duration-dependent manner. Association of antenatal magnesium sulfate use and decreased intestinal morbidities requiring surgery was more distinct in preterm infants <26 weeks of gestational age.http://www.sciencedirect.com/science/article/pii/S1875957220302229extremely premature infantmagnesium sulfatenecrotizing enterocolitisspontaneous intestinal perforation |
| spellingShingle | Seh Hyun Kim Yoo-Jin Kim Seung Hyun Shin Hannah Cho Seung Han Shin Ee-Kyung Kim Han-Suk Kim Subeen Hong Seung Mi Lee Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age Pediatrics and Neonatology extremely premature infant magnesium sulfate necrotizing enterocolitis spontaneous intestinal perforation |
| title | Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| title_full | Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| title_fullStr | Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| title_full_unstemmed | Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| title_short | Antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| title_sort | antenatal magnesium sulfate and intestinal morbidities in preterm infants with extremely low gestational age |
| topic | extremely premature infant magnesium sulfate necrotizing enterocolitis spontaneous intestinal perforation |
| url | http://www.sciencedirect.com/science/article/pii/S1875957220302229 |
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