A systematic review and meta-analysis on how different dexamethasone administration regimes impact total joint arthroplasty outcomes

A systematic review and meta-analysis on how different dexamethasone administration regimes impact total joint arthroplasty outcomes

BackgroundPostoperative pain following total joint arthroplasty is a critical factor influencing patient recovery. This meta-analysis evaluated the efficacy and safety of single-dose, repeated-dose, and split-dose perioperative dexamethasone regimens for managing postoperative pain in patients under...

Full description

Saved in:

Bibliographic Details
Main Authors:	Can Wang, Chenjing Luo, Xiaoxue Tang, Li Luo, Yuerong Zeng, Yumei Zhang, Xuan Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	total knee arthroplasty total hip arthroplasty dexamethasone repeated-dose treatment split-dose treatment single-dose treatment
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1548126/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Declining Service Labor Rates for Total Hip and Total Knee Arthroplasty in Medicare Patients
by: John M. Dundon, MD, FAAOS, et al.
Published: (2025-06-01)

Comparison of analgesic effects between betamethasone and dexamethasone in total knee arthroplasty: a prospective randomized controlled trial
by: Kai Qin, et al.
Published: (2025-07-01)

Predictive Factors for Return to Driving After Lower Limb Arthroplasty
by: Vasileios Giannoudis, MBChB, MRes, et al.
Published: (2025-06-01)

Liposomal bupivacaine versus standard periarticular injections in total hip and knee arthroplasty: a prospective, randomized non-inferiority trial
by: Bowen Joseph, et al.
Published: (2025-01-01)

Perioperative intravenous dexamethasone did not reduce the severity of persistent postsurgical pain after total knee arthroplasty: a prospective, randomized, double-blind, placebo-controlled trial
by: Nitchanant Kitcharanant, et al.
Published: (2024-12-01)

A Video-Based Intervention for Increasing Health Literacy in Total Joint Arthroplasty Patients at a Safety-Net Hospital: A Prospective Single-Blind Cohort Study
by: Sung Jun Son, MD, MS, et al.
Published: (2024-12-01)

Cefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty
by: Meera M. Dhodapkar, MD, MHS, et al.
Published: (2025-02-01)

Clinical benefit of physical rehabilitation after total hip and knee arthroplasty: A pragmatic, randomized, controlled trial (The DRAW1 trial)
by: T. Mark-Christensen, et al.
Published: (2024-12-01)

Systemic antibiotic prophylaxis in arthroplasty – a narrative review of how many doses are optimal
by: Peter Wahl, et al.
Published: (2024-12-01)

Heterotopic ossification (HO) prophylaxis in total hip arthroplasty (THA): A systematic review of level I and level II evidence since 2000
by: Troy B. Puga, et al.
Published: (2025-03-01)

A Collaborative Multimodal Pain Management Pathway Reduces Opiate Consumption After Total Hip and Knee Arthroplasty
by: Mahmoud Khellah, BS, et al.
Published: (2025-06-01)

Comparison of Per-Operative Outcomes between Simultaneous and Staged Bilateral Total Hip Arthroplasties
by: S Hiranya Kumar, et al.
Published: (2025-06-01)

Opioid-free postoperative pain management in total knee and hip arthroplasty: A scoping review
by: Olivia K. Blaber, et al.
Published: (2025-04-01)

Bilateral Total Hip and Right Knee Arthroplasty in a Sickle Cell Disease Patient with Multiple Joint Osteonecrosis: A Case Report and Literature Review
by: Michael Ebiyon Ugbeye, et al.
Published: (2024-12-01)

Declines in Blood Transfusions in Total Hip and Knee Arthroplasties: A Nationwide Population-based Study
by: Yu-Chun Liu, et al.
Published: (2022-09-01)

Predicting 30-Day Venous Thromboembolism Following Total Joint Arthroplasty: Adjusting for Trends in Annual Length of Stay
by: Johnathan R. Lex, MBChB, MASc, et al.
Published: (2024-12-01)

Staff education compared with active real-time waste segregation to reduce the environmental impact of hip and knee arthroplasty: a multicentre study
by: Rohan Prakash, et al.
Published: (2024-12-01)

Revision Total Hip Arthroplasty — What Are We to Expect?
by: Igor I. Shubnyakov, et al.
Published: (2025-06-01)

The utility of robotic-assisted surgery in total knee arthroplasty for moderate and severe valgus deformities: a case series
by: Charles Poh Thean Ang, et al.
Published: (2025-02-01)

Surgical Fear and Related Factors Before Total Knee Arthroplasty
by: Esra Kuşçu, et al.
Published: (2025-07-01)

A systematic comparative analysis of gait characteristics in patients undergoing total knee arthroplasty and unicompartmental knee arthroplasty: a review study
by: Ming Zhang, et al.
Published: (2024-12-01)

The health-economic burden of hip and knee periprosthetic joint infections in Europe: a comprehensive analysis following primary arthroplasty
by: Volker Alt, et al.
Published: (2025-03-01)

Patient perceptions regarding ambulatory knee arthroplasties in China
by: Guanghui Zhao, et al.
Published: (2025-06-01)

The direction of increasing effectiveness of the treatment of periprosthetic joint infection
by: A. V. Shabunin, et al.
Published: (2023-11-01)

The incidence of venous thromboembolism is low when risk stratification-based thromboprophylaxis is used after fast-track hip and knee arthroplasty
by: Annette M Moisander, et al.
Published: (2024-12-01)

Difficulty of diagnostic accuracy of periprosthetic joint infection: a retrospective analysis of revision surgery of total hip arthroplasty and total knee arthroplasty in a tertiary hospital
by: Alexander Herbert Andres, et al.
Published: (2024-12-01)

Bilateral Outpatient Total Knee Arthroplasty – Is it Feasible, Safe, and Worth Considering: A Pilot Study
by: Sunil Rajan, et al.
Published: (2023-01-01)

The Perioperative Resource Use and Effectiveness of Patellofemoral Arthroplasty Versus Total Knee Arthroplasty: A Meta‐Analysis
by: Ziying Wu, et al.
Published: (2025-07-01)

Improved Walking Steadiness Following total Hip Arthroplasty Compared to Total Knee Arthroplasty
by: Kevin A. Wu, BS, et al.
Published: (2025-10-01)

Does robotic arm-assisted total knee arthroplasty have a role to play in large deformities?
by: Vermorel Pierre-Henri, et al.
Published: (2024-01-01)

Medial Patellar Instability Following Total Knee Arthroplasty
by: Joseph P. Barbera, MD, et al.
Published: (2024-12-01)

A Not-So-Pleasant Surprise: Ochronotic Knee Encountered During Primary Arthroplasty
by: Bana Awad, et al.
Published: (2025-05-01)

Home-Based vs. Clinic-Based Rehabilitation After Joint Arthroplasty: A Prospective Matched Cohort Study
by: Erminia Cofano, et al.
Published: (2025-04-01)

Current Rates and Trends of Venous Thromboembolism After Total Hip and Knee Arthroplasty: An Updated Analysis Utilizing the NSQIP Database
by: Hannah Mosher, BS, et al.
Published: (2025-06-01)

Highlights of the 2024 American Joint Replacement Registry Annual Report
by: Christopher N. Carender, MD, et al.
Published: (2025-06-01)

Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains
by: Joshua M. Bonsel, et al.
Published: (2025-05-01)

A Revision of an Infected Total Hip Arthroplasty leading to Oxalate Nephropathy: A Case Report
by: Dimitrios Mouselimis, et al.
Published: (2025-04-01)

Trends in large joint total arthroplasty in patients with rheumatic diseases: an experience of a specialized department of traumatology and orthopedics
by: I. G. Kushnareva, et al.
Published: (2023-12-01)

Use of Bone Bank Grafts in Revision Total Hip Arthroplasty: Patient Characteristics at a Referral Center
by: Thiago de Carvalho Gontijo, et al.
Published: (2025-07-01)

Impact of preoperative nutritional impairment on physical function early after total hip arthroplasty
by: Tsutomu Fujita, et al.
Published: (2025-06-01)