Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications
This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application. BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix. M...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724003888 |
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| author | Mojtaba Ansari Shiva Mahdavikia Hossein Eslami Mozhdeh Saghalaini Hamid Taghipour Fatemeh Zare Shahin Shirani Mohammad Hossein Alizadeh Roknabadi |
| author_facet | Mojtaba Ansari Shiva Mahdavikia Hossein Eslami Mozhdeh Saghalaini Hamid Taghipour Fatemeh Zare Shahin Shirani Mohammad Hossein Alizadeh Roknabadi |
| author_sort | Mojtaba Ansari |
| collection | DOAJ |
| description | This study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application. BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix. Mg/1.5 wt.% CNT composites were reinforced with BAG at weight fractions of 0.5, 1.0, and 1.5 wt.% using spark plasma sintering at 450 °C and 50 MPa after homogenization via ball milling. The cellular bioactivity of these nanocomposites was evaluated using human osteoblast-like cells and adipose-derived mesenchymal stromal cells. The proliferation and attachment of MG-63 cells were assessed and visualized using the methylthiazol tetrazolium (MTT) assay and SEM, while AD-MSC differentiation was measured using alkaline phosphatase activity assays. Histograms were also generated to visualize the diameter distributions of particles in SEM images using image processing techniques. The Mg/CNTs/0.5 wt.% BAG composite demonstrated optimal mechanical properties, with compressive strength, yield strength, and fracture strain of 259.75 MPa, 180.25 MPa, and 31.65%, respectively. Machine learning models, including CNN, LSTM, and GRU, were employed to predict stress-strain relationships across varying BAG amounts, aiming to accurately model these curves without requiring extensive physical experiments. As shown by contact angle measurements, enhanced hydrophilicity promoted better cell adhesion and proliferation. Furthermore, corrosion resistance improved with a higher BAG content. This study concludes that Mg/CNTs composites reinforced with BAG concentrations below 1.0 wt.% offer promising biodegradable implant materials for orthopedic applications, featuring adequate load-bearing capacity and improved corrosion resistance. |
| format | Article |
| id | doaj-art-238b0ed75c4448ee8462f19776ccc922 |
| institution | Kabale University |
| issn | 2213-9567 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-238b0ed75c4448ee8462f19776ccc9222025-01-10T04:37:59ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672024-12-01121251445163Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applicationsMojtaba Ansari0Shiva Mahdavikia1Hossein Eslami2Mozhdeh Saghalaini3Hamid Taghipour4Fatemeh Zare5Shahin Shirani6Mohammad Hossein Alizadeh Roknabadi7Department of Biomedical Engineering, Meybod University, Meybod, Iran; Corresponding author.Department of Biomedical Engineering, Meybod University, Meybod, IranDepartment of Biomedical Engineering, Meybod University, Meybod, IranDepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, IranCenter for Education and Research on Macromolecules (CERM), CESAM Research Unit, Department of Chemistry, University of Liège, Liège, BelgiumDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USADepartment of Biomedical Engineering, Amirkabir University of Technology, Tehran, IranDepartment of Aerospace Engineering, Amirkabir University of Technology, Tehran, IranThis study explores the potential of Mg/Carbon Nanotubes/Baghdadite composites as biomaterials for bone regeneration and repair while addressing the obstacles to their clinical application. BAG powder was synthesized using the sol-gel method to ensure a fine distribution within the Mg/CNTs matrix. Mg/1.5 wt.% CNT composites were reinforced with BAG at weight fractions of 0.5, 1.0, and 1.5 wt.% using spark plasma sintering at 450 °C and 50 MPa after homogenization via ball milling. The cellular bioactivity of these nanocomposites was evaluated using human osteoblast-like cells and adipose-derived mesenchymal stromal cells. The proliferation and attachment of MG-63 cells were assessed and visualized using the methylthiazol tetrazolium (MTT) assay and SEM, while AD-MSC differentiation was measured using alkaline phosphatase activity assays. Histograms were also generated to visualize the diameter distributions of particles in SEM images using image processing techniques. The Mg/CNTs/0.5 wt.% BAG composite demonstrated optimal mechanical properties, with compressive strength, yield strength, and fracture strain of 259.75 MPa, 180.25 MPa, and 31.65%, respectively. Machine learning models, including CNN, LSTM, and GRU, were employed to predict stress-strain relationships across varying BAG amounts, aiming to accurately model these curves without requiring extensive physical experiments. As shown by contact angle measurements, enhanced hydrophilicity promoted better cell adhesion and proliferation. Furthermore, corrosion resistance improved with a higher BAG content. This study concludes that Mg/CNTs composites reinforced with BAG concentrations below 1.0 wt.% offer promising biodegradable implant materials for orthopedic applications, featuring adequate load-bearing capacity and improved corrosion resistance.http://www.sciencedirect.com/science/article/pii/S2213956724003888Biodegradable materialMagnesium-based compositeCarbon nanotubeBaghdaditeSpark plasma sintering |
| spellingShingle | Mojtaba Ansari Shiva Mahdavikia Hossein Eslami Mozhdeh Saghalaini Hamid Taghipour Fatemeh Zare Shahin Shirani Mohammad Hossein Alizadeh Roknabadi Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications Journal of Magnesium and Alloys Biodegradable material Magnesium-based composite Carbon nanotube Baghdadite Spark plasma sintering |
| title | Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications |
| title_full | Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications |
| title_fullStr | Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications |
| title_full_unstemmed | Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications |
| title_short | Fabrication and characterization of magnesium-based nanocomposites reinforced with Baghdadite and carbon nanotubes for orthopaedical applications |
| title_sort | fabrication and characterization of magnesium based nanocomposites reinforced with baghdadite and carbon nanotubes for orthopaedical applications |
| topic | Biodegradable material Magnesium-based composite Carbon nanotube Baghdadite Spark plasma sintering |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724003888 |
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