The Role of Uterine Infection in Pregnancy Outcome: A Case Report
It was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the ascension of microbes. Nowadays, many studies using new sequencing technologies examining microbiomes with low biomass show that the microorgan...
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| Format: | Article |
| Language: | English |
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Medical University - Pleven
2021-12-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34608/download/pdf/ |
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| author | Tatyana Bodurska Emiliana Konova Svetlana Pachkova Angel Yordabnov |
| author_facet | Tatyana Bodurska Emiliana Konova Svetlana Pachkova Angel Yordabnov |
| author_sort | Tatyana Bodurska |
| collection | DOAJ |
| description | It was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the ascension of microbes. Nowadays, many studies using new sequencing technologies examining microbiomes with low biomass show that the microorganisms are gradually changing from the lower to the upper genital tract with decreasing bacterial abundance and increasing bacterial diversity. It is well documented that the endometrium is a non-sterile area, and in healthy women, the Lactobacillus spp. is the dominant flora. Lactobacillus - as a dominant endometrial microbiome, has a crucial role in implantation, early pregnancy development. It is also essential for a good pregnancy outcome. Non-Lactobacillus-dominant microbiome is associated with poor reproductive outcomes (recurrent implantation failure, recurrent miscarriages, outgoing pregnancy). This association is evidence of its significance for reproductive health. We present a case of unsuccessful first pregnancy with concurrent bacterial endometrial infection. A definitive antibiotic treatment resulted in a successful full-term second pregnancy. We present the influence of pathogenic microorganisms on uterine function and pregnancy development, current possibilities for diagnosis and treatment. |
| format | Article |
| id | doaj-art-237ee91d8c5a4a098a8543d77f4026fe |
| institution | DOAJ |
| issn | 1313-9053 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-237ee91d8c5a4a098a8543d77f4026fe2025-08-20T02:45:42ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532021-12-0114217818110.2478/jbcr-2021-002234608The Role of Uterine Infection in Pregnancy Outcome: A Case ReportTatyana BodurskaEmiliana KonovaSvetlana PachkovaAngel YordabnovIt was believed in the past that only the lower genital tract is inhabited by microorganisms, and the cervix was considered as a perfect barrier against the ascension of microbes. Nowadays, many studies using new sequencing technologies examining microbiomes with low biomass show that the microorganisms are gradually changing from the lower to the upper genital tract with decreasing bacterial abundance and increasing bacterial diversity. It is well documented that the endometrium is a non-sterile area, and in healthy women, the Lactobacillus spp. is the dominant flora. Lactobacillus - as a dominant endometrial microbiome, has a crucial role in implantation, early pregnancy development. It is also essential for a good pregnancy outcome. Non-Lactobacillus-dominant microbiome is associated with poor reproductive outcomes (recurrent implantation failure, recurrent miscarriages, outgoing pregnancy). This association is evidence of its significance for reproductive health. We present a case of unsuccessful first pregnancy with concurrent bacterial endometrial infection. A definitive antibiotic treatment resulted in a successful full-term second pregnancy. We present the influence of pathogenic microorganisms on uterine function and pregnancy development, current possibilities for diagnosis and treatment.https://jbcr.arphahub.com/article/34608/download/pdf/endometrial microbiomeLactobacillusendometriti |
| spellingShingle | Tatyana Bodurska Emiliana Konova Svetlana Pachkova Angel Yordabnov The Role of Uterine Infection in Pregnancy Outcome: A Case Report Journal of Biomedical & Clinical Research endometrial microbiome Lactobacillus endometriti |
| title | The Role of Uterine Infection in Pregnancy Outcome: A Case Report |
| title_full | The Role of Uterine Infection in Pregnancy Outcome: A Case Report |
| title_fullStr | The Role of Uterine Infection in Pregnancy Outcome: A Case Report |
| title_full_unstemmed | The Role of Uterine Infection in Pregnancy Outcome: A Case Report |
| title_short | The Role of Uterine Infection in Pregnancy Outcome: A Case Report |
| title_sort | role of uterine infection in pregnancy outcome a case report |
| topic | endometrial microbiome Lactobacillus endometriti |
| url | https://jbcr.arphahub.com/article/34608/download/pdf/ |
| work_keys_str_mv | AT tatyanabodurska theroleofuterineinfectioninpregnancyoutcomeacasereport AT emilianakonova theroleofuterineinfectioninpregnancyoutcomeacasereport AT svetlanapachkova theroleofuterineinfectioninpregnancyoutcomeacasereport AT angelyordabnov theroleofuterineinfectioninpregnancyoutcomeacasereport AT tatyanabodurska roleofuterineinfectioninpregnancyoutcomeacasereport AT emilianakonova roleofuterineinfectioninpregnancyoutcomeacasereport AT svetlanapachkova roleofuterineinfectioninpregnancyoutcomeacasereport AT angelyordabnov roleofuterineinfectioninpregnancyoutcomeacasereport |