Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination
Genetic susceptibility plays an important role in the risk of developing chronic complications in patients with type 2 diabetes mellitus (T2DM). Aims. In this study, we evaluated the possible association of the polymorphic variants that encode key renal damage mediators (endothelial dysfunction, li...
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Endocrinology Research Centre
2014-10-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6693 |
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| author | Anna Viktorovna Zheleznyakova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Valery Vyacheslavovich Nosikov Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_facet | Anna Viktorovna Zheleznyakova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Valery Vyacheslavovich Nosikov Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_sort | Anna Viktorovna Zheleznyakova |
| collection | DOAJ |
| description | Genetic susceptibility plays an important role in the risk of developing chronic complications in patients with type 2 diabetes mellitus (T2DM). Aims. In this study, we evaluated the possible association of the polymorphic variants that encode key renal damage mediators (endothelial dysfunction, lipid metabolism and insulin secretion/sensitivity) with the risk of chronic kidney disease (CKD) in patients with T2DM. Materials and Methods. We enrolled 435 patients with T2DM using case-control study design. In 253 patients, we used non-overlapping criteria to form groups with/without CKD (defined as GFR=10 years) (n=75 and 178, respectively) and analysed the following 4 polymorphic markers: I/D in ACE, ecNOS4a/4b in NOS3, I/D in APOB and e2/e3/e4 in APOE genes. We then divided 182 patients in groups with/without CKD (n=38 and 144, respectively) regardless of the duration of diabetes and studied pro12ala in PPARG2, rs5219 in KCNJ11, rs12255372 in TCF7L2 and rs13266634 in SLC30A8 genes. 2 test, and data were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Values of p |
| format | Article |
| id | doaj-art-237d2a0144b948ea8e9f69bc14592804 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-237d2a0144b948ea8e9f69bc145928042025-08-20T03:09:03ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782014-10-01173233010.14341/DM2014323-306516Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combinationAnna Viktorovna Zheleznyakova0Nadezhda Olegovna Lebedeva1Olga Konstantinovna Vikulova2Valery Vyacheslavovich Nosikov3Minara Shamkhalovna Shamkhalova4Marina Vladimirovna Shestakova5Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, Moscow; Sechenov First Moscow State Medical University, MoscowNational Research Center ‘GosNII Genetika’, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, Moscow; Sechenov First Moscow State Medical University, MoscowGenetic susceptibility plays an important role in the risk of developing chronic complications in patients with type 2 diabetes mellitus (T2DM). Aims. In this study, we evaluated the possible association of the polymorphic variants that encode key renal damage mediators (endothelial dysfunction, lipid metabolism and insulin secretion/sensitivity) with the risk of chronic kidney disease (CKD) in patients with T2DM. Materials and Methods. We enrolled 435 patients with T2DM using case-control study design. In 253 patients, we used non-overlapping criteria to form groups with/without CKD (defined as GFR=10 years) (n=75 and 178, respectively) and analysed the following 4 polymorphic markers: I/D in ACE, ecNOS4a/4b in NOS3, I/D in APOB and e2/e3/e4 in APOE genes. We then divided 182 patients in groups with/without CKD (n=38 and 144, respectively) regardless of the duration of diabetes and studied pro12ala in PPARG2, rs5219 in KCNJ11, rs12255372 in TCF7L2 and rs13266634 in SLC30A8 genes. 2 test, and data were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Values of phttps://www.dia-endojournals.ru/jour/article/view/6693diabetes mellitusgenesckdnos3apobtcf7l2kcnj11 |
| spellingShingle | Anna Viktorovna Zheleznyakova Nadezhda Olegovna Lebedeva Olga Konstantinovna Vikulova Valery Vyacheslavovich Nosikov Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination Сахарный диабет diabetes mellitus genes ckd nos3 apob tcf7l2 kcnj11 |
| title | Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination |
| title_full | Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination |
| title_fullStr | Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination |
| title_full_unstemmed | Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination |
| title_short | Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination |
| title_sort | risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in nos3 apob kcnj11 tcf7l2 genes as compound effect of risk genotypes combination |
| topic | diabetes mellitus genes ckd nos3 apob tcf7l2 kcnj11 |
| url | https://www.dia-endojournals.ru/jour/article/view/6693 |
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