PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER
The characteristics of calpain and proteasome systems in different molecular subtypes of breast cancer were studied. Tumor samples were obtained from 147 breast cancer patients, who were not previously treated with neoadjuvant therapy. Changes in the chymotrypsin-like proteasome activity and the cor...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2017-07-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/538 |
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| author | E. E. Shashova A. V. Doroshenko L. N. Bondar E. M. Slonimskaya I. V. Kondakova |
| author_facet | E. E. Shashova A. V. Doroshenko L. N. Bondar E. M. Slonimskaya I. V. Kondakova |
| author_sort | E. E. Shashova |
| collection | DOAJ |
| description | The characteristics of calpain and proteasome systems in different molecular subtypes of breast cancer were studied. Tumor samples were obtained from 147 breast cancer patients, who were not previously treated with neoadjuvant therapy. Changes in the chymotrypsin-like proteasome activity and the correlation between proteasome and calpain activities were shown in different molecular subtypes of breast cancer. No changes in the calpain activity and proteasome subunits specific for various molecular subtypes of breast cancer were found. Our results show that the proteasome function undergoes changes depending on the receptor expression by tumor cells and this aspect should be further investigated. |
| format | Article |
| id | doaj-art-237c11c4bad64dfcbeb3516eb0ebd342 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2017-07-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-237c11c4bad64dfcbeb3516eb0ebd3422025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-07-01163333910.21294/1814-4861-2017-16-3-33-39448PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCERE. E. Shashova0A. V. Doroshenko1L. N. Bondar2E. M. Slonimskaya3I. V. Kondakova4I.V. Kondakova1 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskI.V. Kondakova1 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskI.V. Kondakova1 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskI.V. Kondakova1 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk; Siberian State Medical University, Russia, TomskI.V. Kondakova1 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, TomskThe characteristics of calpain and proteasome systems in different molecular subtypes of breast cancer were studied. Tumor samples were obtained from 147 breast cancer patients, who were not previously treated with neoadjuvant therapy. Changes in the chymotrypsin-like proteasome activity and the correlation between proteasome and calpain activities were shown in different molecular subtypes of breast cancer. No changes in the calpain activity and proteasome subunits specific for various molecular subtypes of breast cancer were found. Our results show that the proteasome function undergoes changes depending on the receptor expression by tumor cells and this aspect should be further investigated.https://www.siboncoj.ru/jour/article/view/538molecular subtypes of breast cancerсhymotrypsin-like activity of proteasomescaspase-like activity of proteasomessubunits of proteasomescalpain activity |
| spellingShingle | E. E. Shashova A. V. Doroshenko L. N. Bondar E. M. Slonimskaya I. V. Kondakova PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER Сибирский онкологический журнал molecular subtypes of breast cancer сhymotrypsin-like activity of proteasomes caspase-like activity of proteasomes subunits of proteasomes calpain activity |
| title | PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER |
| title_full | PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER |
| title_fullStr | PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER |
| title_full_unstemmed | PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER |
| title_short | PROTEASOMAL AND CALPAIN PROTEOLYSIS SYSTEMS IN DIFFERENT MOLECULAR SUBTYPES OF BREAST CANCER |
| title_sort | proteasomal and calpain proteolysis systems in different molecular subtypes of breast cancer |
| topic | molecular subtypes of breast cancer сhymotrypsin-like activity of proteasomes caspase-like activity of proteasomes subunits of proteasomes calpain activity |
| url | https://www.siboncoj.ru/jour/article/view/538 |
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