HEREDITARY BREAST CANCER
Hereditary breast cancer occurs in 5–20 % of cases and it is associated with inherited mutations in particular genes, such as BRCA1 и BRCA2 in most cases. The CHEK2, PTEN, TP53, ATM, RAD51, BLM, PALB2, Nbs genes are associated with low and median risks ofdeveloping breast cancer. Molecular genetic s...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/85 |
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| _version_ | 1849253233355128832 |
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| author | E. M. Bit-Sava N. B. Belogurova |
| author_facet | E. M. Bit-Sava N. B. Belogurova |
| author_sort | E. M. Bit-Sava |
| collection | DOAJ |
| description | Hereditary breast cancer occurs in 5–20 % of cases and it is associated with inherited mutations in particular genes, such as BRCA1 и BRCA2 in most cases. The CHEK2, PTEN, TP53, ATM, RAD51, BLM, PALB2, Nbs genes are associated with low and median risks ofdeveloping breast cancer. Molecular genetic studies identify germinal mutations underlying hereditary breast cancer. In most cases hereditary breast cancer refers to triple-negative phenotype, which is the most aggressive type of breast cancer, that does not express the genes for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The review presents the diagnostic and treatment methods of hereditary breast cancer. Clinical-morphological aspects allow the new diagnostic and treatment methods of hereditary breast cancer to be identified. Poly (ADP-ribose) polymerase (PARP) inhibitors demonstrate the potential for effective treatment of BRCA-associated breast cancer. |
| format | Article |
| id | doaj-art-237b9ed4ae8f4c7fa6aa36ad47d5a267 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-237b9ed4ae8f4c7fa6aa36ad47d5a2672025-08-20T03:56:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0101758185HEREDITARY BREAST CANCERE. M. Bit-Sava0N. B. Belogurova1St-Petersburg State Pediatric Medical Academy, St-Petersburg I.P. Pavlov State Medical UniversitySt-Petersburg State Pediatric Medical Academy, St-Petersburg I.P. Pavlov State Medical UniversityHereditary breast cancer occurs in 5–20 % of cases and it is associated with inherited mutations in particular genes, such as BRCA1 и BRCA2 in most cases. The CHEK2, PTEN, TP53, ATM, RAD51, BLM, PALB2, Nbs genes are associated with low and median risks ofdeveloping breast cancer. Molecular genetic studies identify germinal mutations underlying hereditary breast cancer. In most cases hereditary breast cancer refers to triple-negative phenotype, which is the most aggressive type of breast cancer, that does not express the genes for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The review presents the diagnostic and treatment methods of hereditary breast cancer. Clinical-morphological aspects allow the new diagnostic and treatment methods of hereditary breast cancer to be identified. Poly (ADP-ribose) polymerase (PARP) inhibitors demonstrate the potential for effective treatment of BRCA-associated breast cancer.https://www.siboncoj.ru/jour/article/view/85brca-associated breast cancertriple-negative breast cancerparp inhibitors |
| spellingShingle | E. M. Bit-Sava N. B. Belogurova HEREDITARY BREAST CANCER Сибирский онкологический журнал brca-associated breast cancer triple-negative breast cancer parp inhibitors |
| title | HEREDITARY BREAST CANCER |
| title_full | HEREDITARY BREAST CANCER |
| title_fullStr | HEREDITARY BREAST CANCER |
| title_full_unstemmed | HEREDITARY BREAST CANCER |
| title_short | HEREDITARY BREAST CANCER |
| title_sort | hereditary breast cancer |
| topic | brca-associated breast cancer triple-negative breast cancer parp inhibitors |
| url | https://www.siboncoj.ru/jour/article/view/85 |
| work_keys_str_mv | AT embitsava hereditarybreastcancer AT nbbelogurova hereditarybreastcancer |