Impact of enzymatic isolation on the propagation efficiency of patient-derived colorectal cancer organoids

Abstract Cancer organoids are three-dimensional in vitro models that closely replicate the genetic, phenotypic, and heterogeneity characteristics of original tumors, making them valuable tools in cancer research. However, the lack of standardized protocols limits their broader application. This stud...

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Bibliographic Details
Main Authors: Gizem Calibasi-Kocal, Tolga Sever, Aras Emre Canda, Leman Evren Kadioglu, Halil Ates, Yasemin Basbinar, Ender Ellidokuz
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-97650-8
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