Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression

Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression

Abstract Background Triple-negative breast cancer (TNBC) is a subtype with the worst prognosis and there is still a lack of effective treatment. Exosomes (Exos) secreted by cancer cells to tumor microenvironment play an important role in cancer progression. We have demonstrated that the function of...

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Bibliographic Details
Main Authors: Xuan Wang, Guocui Qi, Kunning Yang, Linlin Ma, Yuansai Kang, Xiaojing Tang, YanTao Han
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Rasal2
Rab27a
Secretory autophagy
Autophagic-exos
TNBC progression
Online Access:https://doi.org/10.1186/s12967-025-06530-2
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