Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine.

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine.

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Oncolytic reovirus is a potential therapeutic for colorectal cancer patients with a mutant KRAS gene. Reovirus hijacks the autophagic machinery and preferentially induces apoptosis in patients with a KRAS mutation. However, reovirus on its own is not currently a viable treatment and requires enhance...

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Bibliographic Details
Main Authors: Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0326029
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