Feasibility of Intensive Chemotherapy in Hereditary Spherocytosis

Background: This study presents a young man with hereditary spherocytosis (HS) who underwent intensive chemotherapy for newly diagnosed diffuse large B-cell lymphoma (DLBCL) and achieved complete remission. This case challenges the idea of HS as a barrier to standard DLBCL treatment. Discussion: By...

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Main Authors: Carrai Valentina, Giubbilei Cristina, Ciceri Manuel, D’Angelo Simona, Nassi Luca, Sordi Benedetta, Vannucchi Alessandro Maria, Puccini Benedetta
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Hematology Reports
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Online Access:https://www.mdpi.com/2038-8330/17/2/11
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Summary:Background: This study presents a young man with hereditary spherocytosis (HS) who underwent intensive chemotherapy for newly diagnosed diffuse large B-cell lymphoma (DLBCL) and achieved complete remission. This case challenges the idea of HS as a barrier to standard DLBCL treatment. Discussion: By meticulously monitoring blood counts and providing timely transfusions, the team successfully mitigated potential complications associated with chemotherapy-induced stress on red blood cells. Conclusions: This experience underscores the importance of a multidisciplinary approach and tailored treatment plans for patients with co-existing conditions, suggesting that HS should not automatically disqualify them from potentially curative therapies for aggressive lymphomas.
ISSN:2038-8330