Effects of M. tuberculosis and HIV-1 infection on in vitro blood-brain barrier function

Effects of M. tuberculosis and HIV-1 infection on in vitro blood-brain barrier function

Abstract Background Tuberculous meningitis is the most severe form of tuberculosis and HIV-1 co-infection worsens the already poor prognosis. However, how Mycobacterium tuberculosis crosses the blood-brain barrier and how HIV-1 influences tuberculous meningitis pathogenesis remains unclear. Methods...

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Bibliographic Details
Main Authors: Alizé Proust, Katalin A. Wilkinson, Robert J. Wilkinson
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Neuroinflammation
Subjects:
Mycobacterium tuberculosis
HIV-1
Blood-brain barrier
Central nervous system
Brain
Excitotoxicity
Online Access:https://doi.org/10.1186/s12974-025-03467-7
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