Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis
Abstract Treating osteoarthritis (OA) associated pain is a challenge with the potential to significantly improve patients lives. Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization at the osteochondral interface, thereby mitigating O...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56727-8 |
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| _version_ | 1823861786298810368 |
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| author | Wenpin Qin Zhangyu Ma Guo Bai Wen Qin Ling Li Dongxiao Hao Yuzhu Wang Jianfei Yan Xiaoxiao Han Wen Niu Lina Niu Kai Jiao |
| author_facet | Wenpin Qin Zhangyu Ma Guo Bai Wen Qin Ling Li Dongxiao Hao Yuzhu Wang Jianfei Yan Xiaoxiao Han Wen Niu Lina Niu Kai Jiao |
| author_sort | Wenpin Qin |
| collection | DOAJ |
| description | Abstract Treating osteoarthritis (OA) associated pain is a challenge with the potential to significantly improve patients lives. Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization at the osteochondral interface, thereby mitigating OA pain and disease progression. The hydrogel is formed by cross-linking aldehyde-phenylboronic acid-modified sodium alginate/polyethyleneimine-grafted protocatechuic acid (OSAP/PPCA) and bevacizumab sustained-release nanoparticles (BGN@Be), termed OSPPB. The dynamic Schiff base bonds and boronic ester bonds allow for injectability, self-healing, and pH/reactive oxygen species dual responsiveness. The OSPPB hydrogel can significantly inhibit angiogenesis and neurogenesis in vitro. In an in vivo OA model, intraarticular injection of OSPPB accelerates the healing process of condyles and alleviates chronic pain by inhibiting neurovascularization at the osteochondral interface. The injectable hydrogel represents a promising technique to treat OA and OA associated pain. |
| format | Article |
| id | doaj-art-236efb198c69435fbcd5143c3926b40a |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-236efb198c69435fbcd5143c3926b40a2025-02-09T12:44:06ZengNature PortfolioNature Communications2041-17232025-02-0116111710.1038/s41467-025-56727-8Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritisWenpin Qin0Zhangyu Ma1Guo Bai2Wen Qin3Ling Li4Dongxiao Hao5Yuzhu Wang6Jianfei Yan7Xiaoxiao Han8Wen Niu9Lina Niu10Kai Jiao11Department of Stomatology, Tangdu Hospital, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital, The Fourth Military Medical UniversityDepartment of Oral Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityState Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, The Fourth Military Medical UniversityDepartment of Stomatology, Tangdu Hospital, The Fourth Military Medical UniversityAbstract Treating osteoarthritis (OA) associated pain is a challenge with the potential to significantly improve patients lives. Here, we report on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block neurovascularization at the osteochondral interface, thereby mitigating OA pain and disease progression. The hydrogel is formed by cross-linking aldehyde-phenylboronic acid-modified sodium alginate/polyethyleneimine-grafted protocatechuic acid (OSAP/PPCA) and bevacizumab sustained-release nanoparticles (BGN@Be), termed OSPPB. The dynamic Schiff base bonds and boronic ester bonds allow for injectability, self-healing, and pH/reactive oxygen species dual responsiveness. The OSPPB hydrogel can significantly inhibit angiogenesis and neurogenesis in vitro. In an in vivo OA model, intraarticular injection of OSPPB accelerates the healing process of condyles and alleviates chronic pain by inhibiting neurovascularization at the osteochondral interface. The injectable hydrogel represents a promising technique to treat OA and OA associated pain.https://doi.org/10.1038/s41467-025-56727-8 |
| spellingShingle | Wenpin Qin Zhangyu Ma Guo Bai Wen Qin Ling Li Dongxiao Hao Yuzhu Wang Jianfei Yan Xiaoxiao Han Wen Niu Lina Niu Kai Jiao Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis Nature Communications |
| title | Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| title_full | Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| title_fullStr | Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| title_full_unstemmed | Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| title_short | Neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| title_sort | neurovascularization inhibiting dual responsive hydrogel for alleviating the progression of osteoarthritis |
| url | https://doi.org/10.1038/s41467-025-56727-8 |
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