DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement

Saved in:
Bibliographic Details
Main Authors: Disha Kashyap, Shozeb Haider, Thomas A. Milne, Michael J. Booth
Format: Article
Language:English
Published: American Chemical Society 2025-07-01
Series:JACS Au
Online Access:https://doi.org/10.1021/jacsau.5c00422
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849224626818777088
author Disha Kashyap
Shozeb Haider
Thomas A. Milne
Michael J. Booth
author_facet Disha Kashyap
Shozeb Haider
Thomas A. Milne
Michael J. Booth
author_sort Disha Kashyap
collection DOAJ
format Article
id doaj-art-236b0da09ad64c9ea53a93af0aa5090f
institution Kabale University
issn 2691-3704
language English
publishDate 2025-07-01
publisher American Chemical Society
record_format Article
series JACS Au
spelling doaj-art-236b0da09ad64c9ea53a93af0aa5090f2025-08-25T07:27:17ZengAmerican Chemical SocietyJACS Au2691-37042025-07-01583799380710.1021/jacsau.5c00422DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand DisplacementDisha Kashyap0Shozeb Haider1Thomas A. Milne2Michael J. Booth3Department of Chemistry, University of Oxford, Oxford, U.K.UCL School of Pharmacy, University College London, London, U.K.MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.Department of Chemistry, University of Oxford, Oxford, U.K.https://doi.org/10.1021/jacsau.5c00422
spellingShingle Disha Kashyap
Shozeb Haider
Thomas A. Milne
Michael J. Booth
DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
JACS Au
title DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
title_full DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
title_fullStr DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
title_full_unstemmed DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
title_short DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement
title_sort dna programmable protein degradation dynamic control of proteolysis targeting chimera activity via dna hybridization and strand displacement
url https://doi.org/10.1021/jacsau.5c00422
work_keys_str_mv AT dishakashyap dnaprogrammableproteindegradationdynamiccontrolofproteolysistargetingchimeraactivityviadnahybridizationandstranddisplacement
AT shozebhaider dnaprogrammableproteindegradationdynamiccontrolofproteolysistargetingchimeraactivityviadnahybridizationandstranddisplacement
AT thomasamilne dnaprogrammableproteindegradationdynamiccontrolofproteolysistargetingchimeraactivityviadnahybridizationandstranddisplacement
AT michaeljbooth dnaprogrammableproteindegradationdynamiccontrolofproteolysistargetingchimeraactivityviadnahybridizationandstranddisplacement