Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials
A novel two-phase aerosolisation mode utilizing porous materials is investigated, aiming to improve aerosol delivery for medical inhalation. Sintered stainless steel filters with varied pore sizes (PS) from 0.2 μm to 7 μm were used to generate aerosols from a 0.9 wt.% sodium chloride solution. Dropl...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Current Directions in Biomedical Engineering |
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| Online Access: | https://doi.org/10.1515/cdbme-2024-2040 |
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| _version_ | 1850055393233862656 |
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| author | Clement Alexander Koch Wolfgang Glasmacher Birgit Pohlmann Gerhard |
| author_facet | Clement Alexander Koch Wolfgang Glasmacher Birgit Pohlmann Gerhard |
| author_sort | Clement Alexander |
| collection | DOAJ |
| description | A novel two-phase aerosolisation mode utilizing porous materials is investigated, aiming to improve aerosol delivery for medical inhalation. Sintered stainless steel filters with varied pore sizes (PS) from 0.2 μm to 7 μm were used to generate aerosols from a 0.9 wt.% sodium chloride solution. Droplet sizes and delivery rates were measured using laser diffraction spectroscopy. Further measurements included shadow imaging. Results indicate that aerosolisation occurs within a specific range of PS with droplet sizes increasing with increasing PS. The droplets generated are suitable for inhalation therapies. A hypothesis is established about the process of droplet formation which states that different PS within the porous material serve distinct functions that contribute to the breakup of liquid films into aerosol particles. Droplet formation is the result of film breakup in pores filled with fluid. This low-energy aerosolisation method has the potential to be used in handheld devices for sensitive drug formulations, overcoming the limitations of current technologies. Further research is needed to optimize the pore size distribution and enhance aerosol generation efficiency. |
| format | Article |
| id | doaj-art-2369cf03cce64828ac0571f850283f74 |
| institution | DOAJ |
| issn | 2364-5504 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj-art-2369cf03cce64828ac0571f850283f742025-08-20T02:51:59ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042024-12-0110416717010.1515/cdbme-2024-2040Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materialsClement Alexander0Koch Wolfgang1Glasmacher Birgit2Pohlmann Gerhard3Fraunhofer ITEM,Hannover, GermanyFraunhofer ITEM,Hannover, GermanyInstitute for Multiphase Processes, An der Universität 1,Garbsen, GermanyFraunhofer Institute for Toxicology und Experimental Medicine (ITEM), Nikolai-Fuchs-Str. 1, 30625Hannover, GermanyA novel two-phase aerosolisation mode utilizing porous materials is investigated, aiming to improve aerosol delivery for medical inhalation. Sintered stainless steel filters with varied pore sizes (PS) from 0.2 μm to 7 μm were used to generate aerosols from a 0.9 wt.% sodium chloride solution. Droplet sizes and delivery rates were measured using laser diffraction spectroscopy. Further measurements included shadow imaging. Results indicate that aerosolisation occurs within a specific range of PS with droplet sizes increasing with increasing PS. The droplets generated are suitable for inhalation therapies. A hypothesis is established about the process of droplet formation which states that different PS within the porous material serve distinct functions that contribute to the breakup of liquid films into aerosol particles. Droplet formation is the result of film breakup in pores filled with fluid. This low-energy aerosolisation method has the potential to be used in handheld devices for sensitive drug formulations, overcoming the limitations of current technologies. Further research is needed to optimize the pore size distribution and enhance aerosol generation efficiency.https://doi.org/10.1515/cdbme-2024-2040porous materialsaerosolisationdroplet sizesaerosol delivery ratefilm breakup |
| spellingShingle | Clement Alexander Koch Wolfgang Glasmacher Birgit Pohlmann Gerhard Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials Current Directions in Biomedical Engineering porous materials aerosolisation droplet sizes aerosol delivery rate film breakup |
| title | Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| title_full | Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| title_fullStr | Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| title_full_unstemmed | Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| title_short | Droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| title_sort | droplet sizes and delivery rates from film breakup aerosolisation mode in porous materials |
| topic | porous materials aerosolisation droplet sizes aerosol delivery rate film breakup |
| url | https://doi.org/10.1515/cdbme-2024-2040 |
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