Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series
Abstract Objective To investigate the clinicopathological characteristics of patients with pyloric gland adenoma (PGA), as well as their prognosis. Methods Data of 30 cases from 24 patients, who had been histologically diagnosed as PGA, was retrospectively analyzed. Clinical characteristics, histopa...
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BMC
2025-07-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-04110-8 |
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| author | Junzhen Hou Fandong Meng Bing Yue Peng Li Ningning Dong |
| author_facet | Junzhen Hou Fandong Meng Bing Yue Peng Li Ningning Dong |
| author_sort | Junzhen Hou |
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| description | Abstract Objective To investigate the clinicopathological characteristics of patients with pyloric gland adenoma (PGA), as well as their prognosis. Methods Data of 30 cases from 24 patients, who had been histologically diagnosed as PGA, was retrospectively analyzed. Clinical characteristics, histopathological features, treatment and prognosis were assessed and analyzed. Results Among the 24 patients, there were 15 females and 9 males, with an average age of 59 years old. Ten cases were located in the stomach, 4 in the duodenal bulb and 16 in the gallbladder. The average maximum diameter was 13.5 mm and morphologically the vast majority were type 0-I. The assessment of the background mucosa identified autoimmune gastritis (AIG), Helicobacter Pylori-associated gastritis and familial adenomatous polyposis (FAP) in the stomach, ectopic gastric mucosa in the duodenum and chronic cholecystitis in the gallbladder. Endoscopic resection was performed on the vast majority of gastric and duodenal cases, while all gallbladder PGAs underwent cholecystectomy. Histologically, 33.3% of PGAs showed high-grade dysplasia. Conclusions Due to malignant potential, it is recommended that PGAs should be completely resected, especially if they are large or show high-grade features. For gastric and duodenal PGAs, endoscopic resection has been proven to be safe and effective. Whether PGAs occurring in the gallbladder and stomach are different tumors still requires more cases for further study. |
| format | Article |
| id | doaj-art-23678533ddb24f579ffc1905f367e4ee |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-23678533ddb24f579ffc1905f367e4ee2025-08-20T03:42:57ZengBMCBMC Gastroenterology1471-230X2025-07-012511810.1186/s12876-025-04110-8Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case seriesJunzhen Hou0Fandong Meng1Bing Yue2Peng Li3Ningning Dong4Department of Gastroenterology, Shijingshan Teaching Hospital of Capital Medical University, Beijing Shijingshan HospitalDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical DevicesDepartment of Pathology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical DevicesDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical DevicesAbstract Objective To investigate the clinicopathological characteristics of patients with pyloric gland adenoma (PGA), as well as their prognosis. Methods Data of 30 cases from 24 patients, who had been histologically diagnosed as PGA, was retrospectively analyzed. Clinical characteristics, histopathological features, treatment and prognosis were assessed and analyzed. Results Among the 24 patients, there were 15 females and 9 males, with an average age of 59 years old. Ten cases were located in the stomach, 4 in the duodenal bulb and 16 in the gallbladder. The average maximum diameter was 13.5 mm and morphologically the vast majority were type 0-I. The assessment of the background mucosa identified autoimmune gastritis (AIG), Helicobacter Pylori-associated gastritis and familial adenomatous polyposis (FAP) in the stomach, ectopic gastric mucosa in the duodenum and chronic cholecystitis in the gallbladder. Endoscopic resection was performed on the vast majority of gastric and duodenal cases, while all gallbladder PGAs underwent cholecystectomy. Histologically, 33.3% of PGAs showed high-grade dysplasia. Conclusions Due to malignant potential, it is recommended that PGAs should be completely resected, especially if they are large or show high-grade features. For gastric and duodenal PGAs, endoscopic resection has been proven to be safe and effective. Whether PGAs occurring in the gallbladder and stomach are different tumors still requires more cases for further study.https://doi.org/10.1186/s12876-025-04110-8Pyloric gland adenomaClinicopathological featuresHigh-grade dysplasiaEndoscopic resection |
| spellingShingle | Junzhen Hou Fandong Meng Bing Yue Peng Li Ningning Dong Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series BMC Gastroenterology Pyloric gland adenoma Clinicopathological features High-grade dysplasia Endoscopic resection |
| title | Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series |
| title_full | Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series |
| title_fullStr | Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series |
| title_full_unstemmed | Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series |
| title_short | Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series |
| title_sort | clinicopathological characteristics of 30 cases of pyloric gland adenoma a single center case series |
| topic | Pyloric gland adenoma Clinicopathological features High-grade dysplasia Endoscopic resection |
| url | https://doi.org/10.1186/s12876-025-04110-8 |
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