Macroporous scaffolds based on biomass polymers and their applications in wound healing
The rapid advancement of biomedical polymers has raised significant concerns about the disposal of medical polymer waste. Sustainable biomass materials derived from renewable sources in nature have emerged as promising alternatives to petroleum-based polymers for medical applications and tissue engi...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-02-01
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| Series: | Journal of Bioresources and Bioproducts |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S236996982400080X |
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| author | Daqian Gao William D. Shipman Yaping Sun Joshua Zev Glahn Leleda Beraki Henry C. Hsia |
| author_facet | Daqian Gao William D. Shipman Yaping Sun Joshua Zev Glahn Leleda Beraki Henry C. Hsia |
| author_sort | Daqian Gao |
| collection | DOAJ |
| description | The rapid advancement of biomedical polymers has raised significant concerns about the disposal of medical polymer waste. Sustainable biomass materials derived from renewable sources in nature have emerged as promising alternatives to petroleum-based polymers for medical applications and tissue engineering due to their abundance, biodegradability, and environmental friendliness. In tissue engineering, interconnected macropores within biomaterials are crucial as they provide space and interfaces for cells, enhancing permeability for nutrient and waste transport. In this review, we summarize recent developments in the use of biomass materials to engineer macroporous tissue engineering scaffolds. We highlight key techniques, such as microparticles assembly, leaching template, and bioprinting that can create macropores within scaffolds composed of biomass materials and their composites. In addition, we investigate the applications of the macroporous scaffolds in wound healing, with a focus on cell behaviors within macroporous constructs and their role in treating chronic wounds. We envision that the combination of the bicontinuous macropores and biomass-based materials can create an ideal cellular environment and provide a powerful platform for wound healing and tissue regeneration. |
| format | Article |
| id | doaj-art-236762fff22f43048d7b28ffcc20a803 |
| institution | Kabale University |
| issn | 2369-9698 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Bioresources and Bioproducts |
| spelling | doaj-art-236762fff22f43048d7b28ffcc20a8032025-01-26T05:04:11ZengKeAi Communications Co., Ltd.Journal of Bioresources and Bioproducts2369-96982025-02-011011431Macroporous scaffolds based on biomass polymers and their applications in wound healingDaqian Gao0William D. Shipman1Yaping Sun2Joshua Zev Glahn3Leleda Beraki4Henry C. Hsia5Division of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, Yale University, New Haven, CT, USA; VA Connecticut Healthcare, West Haven, Connecticut, USA; Corresponding authors.Department of Dermatology, Yale School of Medicine, Yale University, New Haven, Connecticut, USASection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USADivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, Yale University, New Haven, CT, USADepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USADivision of Plastic and Reconstructive Surgery, Department of Surgery, Yale School of Medicine, Yale University, New Haven, CT, USA; VA Connecticut Healthcare, West Haven, Connecticut, USA; Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA; Corresponding authors.The rapid advancement of biomedical polymers has raised significant concerns about the disposal of medical polymer waste. Sustainable biomass materials derived from renewable sources in nature have emerged as promising alternatives to petroleum-based polymers for medical applications and tissue engineering due to their abundance, biodegradability, and environmental friendliness. In tissue engineering, interconnected macropores within biomaterials are crucial as they provide space and interfaces for cells, enhancing permeability for nutrient and waste transport. In this review, we summarize recent developments in the use of biomass materials to engineer macroporous tissue engineering scaffolds. We highlight key techniques, such as microparticles assembly, leaching template, and bioprinting that can create macropores within scaffolds composed of biomass materials and their composites. In addition, we investigate the applications of the macroporous scaffolds in wound healing, with a focus on cell behaviors within macroporous constructs and their role in treating chronic wounds. We envision that the combination of the bicontinuous macropores and biomass-based materials can create an ideal cellular environment and provide a powerful platform for wound healing and tissue regeneration.http://www.sciencedirect.com/science/article/pii/S236996982400080XBiomass materialBioresourceMacroporeTissue engineeringWound healing |
| spellingShingle | Daqian Gao William D. Shipman Yaping Sun Joshua Zev Glahn Leleda Beraki Henry C. Hsia Macroporous scaffolds based on biomass polymers and their applications in wound healing Journal of Bioresources and Bioproducts Biomass material Bioresource Macropore Tissue engineering Wound healing |
| title | Macroporous scaffolds based on biomass polymers and their applications in wound healing |
| title_full | Macroporous scaffolds based on biomass polymers and their applications in wound healing |
| title_fullStr | Macroporous scaffolds based on biomass polymers and their applications in wound healing |
| title_full_unstemmed | Macroporous scaffolds based on biomass polymers and their applications in wound healing |
| title_short | Macroporous scaffolds based on biomass polymers and their applications in wound healing |
| title_sort | macroporous scaffolds based on biomass polymers and their applications in wound healing |
| topic | Biomass material Bioresource Macropore Tissue engineering Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S236996982400080X |
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