Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study.
<h4>Objectives</h4>The strong association between atypical endometrial hyperplasia and endometrial carcinoma is well established, but data on the risk of atypical hyperplasia and carcinoma in Danish women with non-atypical endometrial hyperplasia are almost non-existent. This study aimed...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266339&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850235628443140096 |
|---|---|
| author | Clara M Prip Maria Stentebjerg Mary H Bennetsen Lone K Petersen Pinar Bor |
| author_facet | Clara M Prip Maria Stentebjerg Mary H Bennetsen Lone K Petersen Pinar Bor |
| author_sort | Clara M Prip |
| collection | DOAJ |
| description | <h4>Objectives</h4>The strong association between atypical endometrial hyperplasia and endometrial carcinoma is well established, but data on the risk of atypical hyperplasia and carcinoma in Danish women with non-atypical endometrial hyperplasia are almost non-existent. This study aimed to investigate the prevalence of atypical hyperplasia and endometrial carcinoma diagnosed within 3 months of initial diagnosis (defined as concurrent disease) and the risk of atypical hyperplasia and carcinoma more than 3 months after initial diagnosis (classified as progressive disease) in Danish women initially diagnosed with non-atypical endometrial hyperplasia.<h4>Design</h4>This cohort study recruited 102 women diagnosed with non-atypical endometrial hyperplasia at Randers Regional Hospital in Randers, Denmark, between 2000 and 2015.<h4>Methods</h4>The endometrium was evaluated by transvaginal ultrasound examination and office mini-hysteroscopy with biopsies in all non-hysterectomized women. Data regarding subsequent hysterectomy or endometrial sampling were obtained from medical records and the Danish Pathology Registry (Patobank).<h4>Results</h4>A total of 15 women were diagnosed with atypical hyperplasia or carcinoma during follow-up. Concurrent atypical hyperplasia or carcinoma was seen in 2.9% (3/102), and among women who remained at risk for more than 3 months after initial diagnosis of non-atypical endometrial hyperplasia (n = 94), progression to atypical hyperplasia or carcinoma was seen in 13% (median follow-up 5.2 years, range 3.6 months to 15.1 years). Sixty-six percent of the women with progressive disease were diagnosed with atypical hyperplasia or carcinoma more than 1 year after initial diagnosis, but only two were diagnosed later than 5 years (5.2 and 9 years).<h4>Conclusions</h4>The risk of being diagnosed with atypical endometrial hyperplasia or endometrial carcinoma more than 5 years after an initial diagnosis of non-atypical endometrial hyperplasia seems to be low in Danish women. Specialized follow-up more than 5 years after diagnosis of non-atypical endometrial hyperplasia may not be warranted. |
| format | Article |
| id | doaj-art-23656d5cb6b34b41b10413bd138bb8b1 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-23656d5cb6b34b41b10413bd138bb8b12025-08-20T02:02:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174e026633910.1371/journal.pone.0266339Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study.Clara M PripMaria StentebjergMary H BennetsenLone K PetersenPinar Bor<h4>Objectives</h4>The strong association between atypical endometrial hyperplasia and endometrial carcinoma is well established, but data on the risk of atypical hyperplasia and carcinoma in Danish women with non-atypical endometrial hyperplasia are almost non-existent. This study aimed to investigate the prevalence of atypical hyperplasia and endometrial carcinoma diagnosed within 3 months of initial diagnosis (defined as concurrent disease) and the risk of atypical hyperplasia and carcinoma more than 3 months after initial diagnosis (classified as progressive disease) in Danish women initially diagnosed with non-atypical endometrial hyperplasia.<h4>Design</h4>This cohort study recruited 102 women diagnosed with non-atypical endometrial hyperplasia at Randers Regional Hospital in Randers, Denmark, between 2000 and 2015.<h4>Methods</h4>The endometrium was evaluated by transvaginal ultrasound examination and office mini-hysteroscopy with biopsies in all non-hysterectomized women. Data regarding subsequent hysterectomy or endometrial sampling were obtained from medical records and the Danish Pathology Registry (Patobank).<h4>Results</h4>A total of 15 women were diagnosed with atypical hyperplasia or carcinoma during follow-up. Concurrent atypical hyperplasia or carcinoma was seen in 2.9% (3/102), and among women who remained at risk for more than 3 months after initial diagnosis of non-atypical endometrial hyperplasia (n = 94), progression to atypical hyperplasia or carcinoma was seen in 13% (median follow-up 5.2 years, range 3.6 months to 15.1 years). Sixty-six percent of the women with progressive disease were diagnosed with atypical hyperplasia or carcinoma more than 1 year after initial diagnosis, but only two were diagnosed later than 5 years (5.2 and 9 years).<h4>Conclusions</h4>The risk of being diagnosed with atypical endometrial hyperplasia or endometrial carcinoma more than 5 years after an initial diagnosis of non-atypical endometrial hyperplasia seems to be low in Danish women. Specialized follow-up more than 5 years after diagnosis of non-atypical endometrial hyperplasia may not be warranted.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266339&type=printable |
| spellingShingle | Clara M Prip Maria Stentebjerg Mary H Bennetsen Lone K Petersen Pinar Bor Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. PLoS ONE |
| title | Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. |
| title_full | Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. |
| title_fullStr | Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. |
| title_full_unstemmed | Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. |
| title_short | Risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non-atypical endometrial hyperplasia: A long-term follow-up study. |
| title_sort | risk of atypical hyperplasia and endometrial carcinoma after initial diagnosis of non atypical endometrial hyperplasia a long term follow up study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266339&type=printable |
| work_keys_str_mv | AT claramprip riskofatypicalhyperplasiaandendometrialcarcinomaafterinitialdiagnosisofnonatypicalendometrialhyperplasiaalongtermfollowupstudy AT mariastentebjerg riskofatypicalhyperplasiaandendometrialcarcinomaafterinitialdiagnosisofnonatypicalendometrialhyperplasiaalongtermfollowupstudy AT maryhbennetsen riskofatypicalhyperplasiaandendometrialcarcinomaafterinitialdiagnosisofnonatypicalendometrialhyperplasiaalongtermfollowupstudy AT lonekpetersen riskofatypicalhyperplasiaandendometrialcarcinomaafterinitialdiagnosisofnonatypicalendometrialhyperplasiaalongtermfollowupstudy AT pinarbor riskofatypicalhyperplasiaandendometrialcarcinomaafterinitialdiagnosisofnonatypicalendometrialhyperplasiaalongtermfollowupstudy |