Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents
Diaryliodonium salts are an important part of hypervalent iodine chemistry, owing to their highly electrophilic character, non-toxicity, and air and moisture stability, have been identified as an important arylating agent. It has been widely applied in the synthesis of natural products, drugs, and b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/14/3019 |
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| author | Xiao-Wei Chen Jia-Le Chen Ling-Hui Zhang Huhu Zhang Xiaojun Chen Xiaohui Fan |
| author_facet | Xiao-Wei Chen Jia-Le Chen Ling-Hui Zhang Huhu Zhang Xiaojun Chen Xiaohui Fan |
| author_sort | Xiao-Wei Chen |
| collection | DOAJ |
| description | Diaryliodonium salts are an important part of hypervalent iodine chemistry, owing to their highly electrophilic character, non-toxicity, and air and moisture stability, have been identified as an important arylating agent. It has been widely applied in the synthesis of natural products, drugs, and bioactive molecules bearing active α-arylation carbonyl units. Within the domain of α-arylation of carbonyl compounds using diaryliodonium salts, there is a notable absence in the literature of a comprehensive compilation dedicated to exclusive arylation processes involving these compounds. In this review, we focus on the overview of the recent advancements in utilizing diaryliodonium salts for α-arylation reactions, encompassing both racemic and asymmetric approaches to various carbonyl compounds including ketones, esters, enolates, and amides. Furthermore, we discuss the unique advantages and inherent limitations of diaryliodonium salts as arylating agents, as well as the underexplored application potentials that warrant further investigation in this rapidly evolving field. |
| format | Article |
| id | doaj-art-2362d09ad1ab4eaa840abfc458b73597 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-2362d09ad1ab4eaa840abfc458b735972025-08-20T03:07:58ZengMDPI AGMolecules1420-30492025-07-013014301910.3390/molecules30143019Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating AgentsXiao-Wei Chen0Jia-Le Chen1Ling-Hui Zhang2Huhu Zhang3Xiaojun Chen4Xiaohui Fan5School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, ChinaSchool of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, ChinaState Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, ChinaSchool of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, ChinaAnimal Husbandry and Veterinary Bureau of Anding District, Dingxi 743021, ChinaSchool of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, ChinaDiaryliodonium salts are an important part of hypervalent iodine chemistry, owing to their highly electrophilic character, non-toxicity, and air and moisture stability, have been identified as an important arylating agent. It has been widely applied in the synthesis of natural products, drugs, and bioactive molecules bearing active α-arylation carbonyl units. Within the domain of α-arylation of carbonyl compounds using diaryliodonium salts, there is a notable absence in the literature of a comprehensive compilation dedicated to exclusive arylation processes involving these compounds. In this review, we focus on the overview of the recent advancements in utilizing diaryliodonium salts for α-arylation reactions, encompassing both racemic and asymmetric approaches to various carbonyl compounds including ketones, esters, enolates, and amides. Furthermore, we discuss the unique advantages and inherent limitations of diaryliodonium salts as arylating agents, as well as the underexplored application potentials that warrant further investigation in this rapidly evolving field.https://www.mdpi.com/1420-3049/30/14/3019diaryliodonium saltsα-arylationcarbonyl compoundsarylating agents |
| spellingShingle | Xiao-Wei Chen Jia-Le Chen Ling-Hui Zhang Huhu Zhang Xiaojun Chen Xiaohui Fan Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents Molecules diaryliodonium salts α-arylation carbonyl compounds arylating agents |
| title | Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents |
| title_full | Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents |
| title_fullStr | Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents |
| title_full_unstemmed | Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents |
| title_short | Advances in α-Arylation of Carbonyl Compounds: Diaryliodonium Salts as Arylating Agents |
| title_sort | advances in α arylation of carbonyl compounds diaryliodonium salts as arylating agents |
| topic | diaryliodonium salts α-arylation carbonyl compounds arylating agents |
| url | https://www.mdpi.com/1420-3049/30/14/3019 |
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