Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway

Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway

Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, the efficacy of EGFR-TKIs in wild-type EGFR tumors has been shown to be marginal. Methods that can sensitize EGFR-TKIs t...

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Bibliographic Details
Main Authors: Han Wang, Xiaohui Du, Wenwen Liu, Congcong Zhang, Ying Li, Jingwen Hou, Yi Yu, Guiru Li, Qi Wang
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Respiratory Research
Subjects:
EGFR-TKIs
Betulinic acid
Wild-type EGFR
Autophagic cell death
Cell cycle arrest
Non-small cell lung cancer
Online Access:https://doi.org/10.1186/s12931-024-02844-9
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