SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes

SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes

Abstract Background Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabetes exacerbates this aging process. Sodium-glucose co-transporter 2 inh...

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Main Authors: Yun Wen, Xiaofang Zhang, Han Liu, Haowen Ye, Ruxin Wang, Caixia Ma, Tianqi Duo, Jiaxin Wang, Xian Yang, Meixin Yu, Ying Wang, Liangyan Wu, Yongting Zhao, Lihong Wang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cardiovascular Diabetology
Subjects:
SGLT2i
Diabetic cardiomyopathy
Cellular senescence
ANGPTL4
FOXO1
Online Access:https://doi.org/10.1186/s12933-024-02520-8
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