Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the va...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-10-01
|
| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002298&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850137207673716736 |
|---|---|
| author | Amidou N'Diaye Gary K Chen Cameron D Palmer Bing Ge Bamidele Tayo Rasika A Mathias Jingzhong Ding Michael A Nalls Adebowale Adeyemo Véronique Adoue Christine B Ambrosone Larry Atwood Elisa V Bandera Lewis C Becker Sonja I Berndt Leslie Bernstein William J Blot Eric Boerwinkle Angela Britton Graham Casey Stephen J Chanock Ellen Demerath Sandra L Deming W Ryan Diver Caroline Fox Tamara B Harris Dena G Hernandez Jennifer J Hu Sue A Ingles Esther M John Craig Johnson Brendan Keating Rick A Kittles Laurence N Kolonel Stephen B Kritchevsky Loic Le Marchand Kurt Lohman Jiankang Liu Robert C Millikan Adam Murphy Solomon Musani Christine Neslund-Dudas Kari E North Sarah Nyante Adesola Ogunniyi Elaine A Ostrander George Papanicolaou Sanjay Patel Curtis A Pettaway Michael F Press Susan Redline Jorge L Rodriguez-Gil Charles Rotimi Benjamin A Rybicki Babatunde Salako Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Alex H Stram Daniel O Stram Sara S Strom Bhoom Suktitipat Michael J Thun John S Witte Lisa R Yanek Regina G Ziegler Wei Zheng Xiaofeng Zhu Joseph M Zmuda Alan B Zonderman Michele K Evans Yongmei Liu Diane M Becker Richard S Cooper Tomi Pastinen Brian E Henderson Joel N Hirschhorn Guillaume Lettre Christopher A Haiman |
| author_facet | Amidou N'Diaye Gary K Chen Cameron D Palmer Bing Ge Bamidele Tayo Rasika A Mathias Jingzhong Ding Michael A Nalls Adebowale Adeyemo Véronique Adoue Christine B Ambrosone Larry Atwood Elisa V Bandera Lewis C Becker Sonja I Berndt Leslie Bernstein William J Blot Eric Boerwinkle Angela Britton Graham Casey Stephen J Chanock Ellen Demerath Sandra L Deming W Ryan Diver Caroline Fox Tamara B Harris Dena G Hernandez Jennifer J Hu Sue A Ingles Esther M John Craig Johnson Brendan Keating Rick A Kittles Laurence N Kolonel Stephen B Kritchevsky Loic Le Marchand Kurt Lohman Jiankang Liu Robert C Millikan Adam Murphy Solomon Musani Christine Neslund-Dudas Kari E North Sarah Nyante Adesola Ogunniyi Elaine A Ostrander George Papanicolaou Sanjay Patel Curtis A Pettaway Michael F Press Susan Redline Jorge L Rodriguez-Gil Charles Rotimi Benjamin A Rybicki Babatunde Salako Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Alex H Stram Daniel O Stram Sara S Strom Bhoom Suktitipat Michael J Thun John S Witte Lisa R Yanek Regina G Ziegler Wei Zheng Xiaofeng Zhu Joseph M Zmuda Alan B Zonderman Michele K Evans Yongmei Liu Diane M Becker Richard S Cooper Tomi Pastinen Brian E Henderson Joel N Hirschhorn Guillaume Lettre Christopher A Haiman |
| author_sort | Amidou N'Diaye |
| collection | DOAJ |
| description | Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10(-12) and 2p14-rs4315565, P = 1.2×10(-8)). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10(-4) for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits. |
| format | Article |
| id | doaj-art-235df6289e8c4e67b0d8cbb11e6a5b1a |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-235df6289e8c4e67b0d8cbb11e6a5b1a2025-08-20T02:30:55ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042011-10-01710e100229810.1371/journal.pgen.1002298Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.Amidou N'DiayeGary K ChenCameron D PalmerBing GeBamidele TayoRasika A MathiasJingzhong DingMichael A NallsAdebowale AdeyemoVéronique AdoueChristine B AmbrosoneLarry AtwoodElisa V BanderaLewis C BeckerSonja I BerndtLeslie BernsteinWilliam J BlotEric BoerwinkleAngela BrittonGraham CaseyStephen J ChanockEllen DemerathSandra L DemingW Ryan DiverCaroline FoxTamara B HarrisDena G HernandezJennifer J HuSue A InglesEsther M JohnCraig JohnsonBrendan KeatingRick A KittlesLaurence N KolonelStephen B KritchevskyLoic Le MarchandKurt LohmanJiankang LiuRobert C MillikanAdam MurphySolomon MusaniChristine Neslund-DudasKari E NorthSarah NyanteAdesola OgunniyiElaine A OstranderGeorge PapanicolaouSanjay PatelCurtis A PettawayMichael F PressSusan RedlineJorge L Rodriguez-GilCharles RotimiBenjamin A RybickiBabatunde SalakoPamela J SchreinerLisa B SignorelloAndrew B SingletonJanet L StanfordAlex H StramDaniel O StramSara S StromBhoom SuktitipatMichael J ThunJohn S WitteLisa R YanekRegina G ZieglerWei ZhengXiaofeng ZhuJoseph M ZmudaAlan B ZondermanMichele K EvansYongmei LiuDiane M BeckerRichard S CooperTomi PastinenBrian E HendersonJoel N HirschhornGuillaume LettreChristopher A HaimanAdult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10(-12) and 2p14-rs4315565, P = 1.2×10(-8)). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10(-4) for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002298&type=printable |
| spellingShingle | Amidou N'Diaye Gary K Chen Cameron D Palmer Bing Ge Bamidele Tayo Rasika A Mathias Jingzhong Ding Michael A Nalls Adebowale Adeyemo Véronique Adoue Christine B Ambrosone Larry Atwood Elisa V Bandera Lewis C Becker Sonja I Berndt Leslie Bernstein William J Blot Eric Boerwinkle Angela Britton Graham Casey Stephen J Chanock Ellen Demerath Sandra L Deming W Ryan Diver Caroline Fox Tamara B Harris Dena G Hernandez Jennifer J Hu Sue A Ingles Esther M John Craig Johnson Brendan Keating Rick A Kittles Laurence N Kolonel Stephen B Kritchevsky Loic Le Marchand Kurt Lohman Jiankang Liu Robert C Millikan Adam Murphy Solomon Musani Christine Neslund-Dudas Kari E North Sarah Nyante Adesola Ogunniyi Elaine A Ostrander George Papanicolaou Sanjay Patel Curtis A Pettaway Michael F Press Susan Redline Jorge L Rodriguez-Gil Charles Rotimi Benjamin A Rybicki Babatunde Salako Pamela J Schreiner Lisa B Signorello Andrew B Singleton Janet L Stanford Alex H Stram Daniel O Stram Sara S Strom Bhoom Suktitipat Michael J Thun John S Witte Lisa R Yanek Regina G Ziegler Wei Zheng Xiaofeng Zhu Joseph M Zmuda Alan B Zonderman Michele K Evans Yongmei Liu Diane M Becker Richard S Cooper Tomi Pastinen Brian E Henderson Joel N Hirschhorn Guillaume Lettre Christopher A Haiman Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. PLoS Genetics |
| title | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| title_full | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| title_fullStr | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| title_full_unstemmed | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| title_short | Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. |
| title_sort | identification replication and fine mapping of loci associated with adult height in individuals of african ancestry |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002298&type=printable |
| work_keys_str_mv | AT amidoundiaye identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT garykchen identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT camerondpalmer identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT bingge identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT bamideletayo identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT rasikaamathias identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT jingzhongding identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT michaelanalls identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT adebowaleadeyemo identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT veroniqueadoue identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT christinebambrosone identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT larryatwood identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT elisavbandera identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT lewiscbecker identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sonjaiberndt identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT lesliebernstein identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT williamjblot identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT ericboerwinkle identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT angelabritton identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT grahamcasey identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT stephenjchanock identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT ellendemerath identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sandraldeming identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT wryandiver identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT carolinefox identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT tamarabharris identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT denaghernandez identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT jenniferjhu identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sueaingles identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT esthermjohn identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT craigjohnson identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT brendankeating identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT rickakittles identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT laurencenkolonel identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT stephenbkritchevsky identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT loiclemarchand identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT kurtlohman identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT jiankangliu identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT robertcmillikan identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT adammurphy identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT solomonmusani identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT christineneslunddudas identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT karienorth identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sarahnyante identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT adesolaogunniyi identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT elaineaostrander identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT georgepapanicolaou identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sanjaypatel identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT curtisapettaway identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT michaelfpress identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT susanredline identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT jorgelrodriguezgil identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT charlesrotimi identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT benjaminarybicki identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT babatundesalako identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT pamelajschreiner identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT lisabsignorello identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT andrewbsingleton identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT janetlstanford identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT alexhstram identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT danielostram identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT sarasstrom identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT bhoomsuktitipat identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT michaeljthun identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT johnswitte identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT lisaryanek identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT reginagziegler identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT weizheng identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT xiaofengzhu identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT josephmzmuda identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT alanbzonderman identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT michelekevans identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT yongmeiliu identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT dianembecker identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT richardscooper identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT tomipastinen identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT brianehenderson identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT joelnhirschhorn identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT guillaumelettre identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry AT christopherahaiman identificationreplicationandfinemappingoflociassociatedwithadultheightinindividualsofafricanancestry |