Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against Trypanosoma cruzi

Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against Trypanosoma cruzi

Currently, no vaccine is available to prevent Chagas disease. Experimental vaccines against Trypanosoma cruzi (Tc) have shown high protection, but their development for humans still requires further study. Additionally, the sexual dimorphism observed in Chagas disease, with greater resistance in wom...

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Bibliographic Details
Main Authors: Camila Bulfoni Balbi, Maria Florencia Pacini, Brenda Dinatale, Cecilia Farré, Paula Cacik, Estefanía Prochetto, Florencia Belén González, Iván Marcipar, Gabriel Cabrera, Ana Rosa Pérez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
sexual dimorphism
Chagas disease
mucosal vaccines
trans-sialidase
MDSCs
regulatory T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1526573/full
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