Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy
Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a chronic inflammatory disease. Its severe uncontrolled form may share, with asthma and atopic dermatitis, the pathophysiological mechanism of T helper 2 inflammation, characterized by tissue eosinophilia and high local IgE levels. Comorbidities a...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2025.1573764/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694113770766336 |
|---|---|
| author | F. Anastasi F. Anastasi C. Di Nota S. Sessi A. Marzetti A. Sambito M. Della Casa S. Pizzolante G. Bandiera |
| author_facet | F. Anastasi F. Anastasi C. Di Nota S. Sessi A. Marzetti A. Sambito M. Della Casa S. Pizzolante G. Bandiera |
| author_sort | F. Anastasi |
| collection | DOAJ |
| description | Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a chronic inflammatory disease. Its severe uncontrolled form may share, with asthma and atopic dermatitis, the pathophysiological mechanism of T helper 2 inflammation, characterized by tissue eosinophilia and high local IgE levels. Comorbidities and the severity of symptoms result in a poor quality of life. CRSwNP is difficult to treat both medically and surgically. Systemic corticosteroids are widely used to manage signs and symptoms of this disease. However, prolonged use of systemic corticosteroids is associated with numerous side effects that limit their long-term use. Alternative therapy with new biologic drugs allows good control of the signs and symptoms of CRSwNP, without the side effects of systemic corticosteroids. Through an interview proposed to patients affected by CRSwNP, the use of systemic corticosteroids, their dosage and the methods of administration were analyzed in the period preceding the start of therapy with biological drugs and the real impact of biological therapy on corticosteroid use. |
| format | Article |
| id | doaj-art-2357dbb879f74462b560f6aaada44b47 |
| institution | DOAJ |
| issn | 2673-6101 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj-art-2357dbb879f74462b560f6aaada44b472025-08-20T03:20:12ZengFrontiers Media S.A.Frontiers in Allergy2673-61012025-06-01610.3389/falgy.2025.15737641573764Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, ItalyF. Anastasi0F. Anastasi1C. Di Nota2S. Sessi3A. Marzetti4A. Sambito5M. Della Casa6S. Pizzolante7G. Bandiera8Unit of Otorhinolaryngology, Medical and Surgical Rhinology, Ospedale San Giovanni Evangelista, Tivoli, ItalyDepartment Faculty of Medicine, Unicamillus—Saint Camillus International University of Health and Medical Sciences, Rome, ItalyUnit of Otorhinolaryngology and Maxillofacial Surgery, Ospedale F. Spaziani- Frosinone, Frosinone, ItalyUnit of Otorhinolaryngology and Maxillofacial Surgery, Ospedale F. Spaziani- Frosinone, Frosinone, ItalyUnit of Otorhinolaryngology and Maxillofacial Surgery, Ospedale F. Spaziani- Frosinone, Frosinone, ItalyUnit of Otorhinolaryngology, Ospedale Belcolle ASL Viterbo, Viterbo, ItalyUnit of Otorhinolaryngology, Ospedale Belcolle ASL Viterbo, Viterbo, ItalyOtolaryngology Unit, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyOtolaryngology Unit, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyChronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a chronic inflammatory disease. Its severe uncontrolled form may share, with asthma and atopic dermatitis, the pathophysiological mechanism of T helper 2 inflammation, characterized by tissue eosinophilia and high local IgE levels. Comorbidities and the severity of symptoms result in a poor quality of life. CRSwNP is difficult to treat both medically and surgically. Systemic corticosteroids are widely used to manage signs and symptoms of this disease. However, prolonged use of systemic corticosteroids is associated with numerous side effects that limit their long-term use. Alternative therapy with new biologic drugs allows good control of the signs and symptoms of CRSwNP, without the side effects of systemic corticosteroids. Through an interview proposed to patients affected by CRSwNP, the use of systemic corticosteroids, their dosage and the methods of administration were analyzed in the period preceding the start of therapy with biological drugs and the real impact of biological therapy on corticosteroid use.https://www.frontiersin.org/articles/10.3389/falgy.2025.1573764/fullCRSwNPTh2 inflammationsystemic corticosteroidpharmaco economicbiological therapyasthma |
| spellingShingle | F. Anastasi F. Anastasi C. Di Nota S. Sessi A. Marzetti A. Sambito M. Della Casa S. Pizzolante G. Bandiera Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy Frontiers in Allergy CRSwNP Th2 inflammation systemic corticosteroid pharmaco economic biological therapy asthma |
| title | Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy |
| title_full | Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy |
| title_fullStr | Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy |
| title_full_unstemmed | Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy |
| title_short | Efficacy and limitations of systemic corticosteroids in patients with CRSwNP compared to alternative therapies with monoclonal antibodies: real-life of 101 patients from the Lazio region, Italy |
| title_sort | efficacy and limitations of systemic corticosteroids in patients with crswnp compared to alternative therapies with monoclonal antibodies real life of 101 patients from the lazio region italy |
| topic | CRSwNP Th2 inflammation systemic corticosteroid pharmaco economic biological therapy asthma |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2025.1573764/full |
| work_keys_str_mv | AT fanastasi efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT fanastasi efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT cdinota efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT ssessi efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT amarzetti efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT asambito efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT mdellacasa efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT spizzolante efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly AT gbandiera efficacyandlimitationsofsystemiccorticosteroidsinpatientswithcrswnpcomparedtoalternativetherapieswithmonoclonalantibodiesreallifeof101patientsfromthelazioregionitaly |