Associations of maternal alcohol and non-prescribed substance use with early child growth
Background: Perinatal alcohol and non-prescribed substance use may be detrimental to foetal and infant growth. Aim: This observational study investigated how combined and continued alcohol and non-prescribed substance use throughout antenatal and 1-year postnatal periods were associated with advers...
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| Format: | Article |
| Language: | English |
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AOSIS
2025-06-01
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| Series: | South African Journal of Psychiatry |
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| Online Access: | https://sajp.org.za/index.php/sajp/article/view/2486 |
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| author | Yukiko Washio Zugui Zhang Mona Lisa Baishya Marilyn T. Lake Bronwyn Myers Nadia Hoffman Elizabeth Goddard Heather J. Zar Dan J. Stein Petal Petersen Williams |
| author_facet | Yukiko Washio Zugui Zhang Mona Lisa Baishya Marilyn T. Lake Bronwyn Myers Nadia Hoffman Elizabeth Goddard Heather J. Zar Dan J. Stein Petal Petersen Williams |
| author_sort | Yukiko Washio |
| collection | DOAJ |
| description | Background: Perinatal alcohol and non-prescribed substance use may be detrimental to foetal and infant growth.
Aim: This observational study investigated how combined and continued alcohol and non-prescribed substance use throughout antenatal and 1-year postnatal periods were associated with adverse child length and weight outcomes up to 24 months.
Setting: Data from participants (n = 1098) with information on alcohol and non-prescribed substance use and infant and child outcomes, were drawn from a prospective birth cohort in the Drakenstein Child Health Study (DCHS), conducted in the Western Cape province of South Africa.
Methods: Generalised estimating equations were conducted on standardised child length and weight outcomes at 12, 18 and 24 months.
Results: Non-prescribed substances consisted mostly of tobacco use (77%). Child length and weight were significantly lower in those exposed to the combined use of alcohol and substances compared to no-use and all other use groups (p 0.001), as confirmed by multivariable analyses. Child length and weight were also significantly lower in those exposed to alcohol and/or substance use throughout the antenatal and 1-year postnatal periods, as confirmed by multivariable analyses.
Conclusion: Interventions to address the potential long-term adverse effects of combined alcohol and substance use particularly tobacco use, as well as continuous use throughout antenatal and early postnatal periods on subsequent child growth, are needed.
Contribution: This study has contributed to the field by showing that combined and continued use of alcohol and other substances during pregnancy and postpartum is associated with impaired early child growth. |
| format | Article |
| id | doaj-art-2350fb92ef7c41b8a3adbf56fa57ca70 |
| institution | Kabale University |
| issn | 1608-9685 2078-6786 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Psychiatry |
| spelling | doaj-art-2350fb92ef7c41b8a3adbf56fa57ca702025-08-20T03:28:34ZengAOSISSouth African Journal of Psychiatry1608-96852078-67862025-06-01310e1e910.4102/sajpsychiatry.v31i0.2486787Associations of maternal alcohol and non-prescribed substance use with early child growthYukiko Washio0Zugui Zhang1Mona Lisa Baishya2Marilyn T. Lake3Bronwyn Myers4Nadia Hoffman5Elizabeth Goddard6Heather J. Zar7Dan J. Stein8Petal Petersen Williams9Women’s Global Health Imperative, RTI International, Media, Pennsylvania Department of Obstetrics, Gynecology and Reproductive Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PennsylvaniaiREACH, Christiana Care, Newark, DelawareCollege of Public Health, Temple University, Philadelphia, PennsylvaniaSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape TownenAble Institute, Curtin University, BentleySAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape TownSAMRC Unit on Child and Adolescent Health, Department of Pediatrics, University of Cape Town, Cape TownSAMRC Unit on Child and Adolescent Health, Department of Pediatrics, University of Cape Town, Cape TownSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape TownMental Health, Alcohol, Substance Use and Tobacco Research Unit, South African Medical Research Council Institute for Life Course Health Research, Department of Global Health, Stellenbosch University, Cape TownBackground: Perinatal alcohol and non-prescribed substance use may be detrimental to foetal and infant growth. Aim: This observational study investigated how combined and continued alcohol and non-prescribed substance use throughout antenatal and 1-year postnatal periods were associated with adverse child length and weight outcomes up to 24 months. Setting: Data from participants (n = 1098) with information on alcohol and non-prescribed substance use and infant and child outcomes, were drawn from a prospective birth cohort in the Drakenstein Child Health Study (DCHS), conducted in the Western Cape province of South Africa. Methods: Generalised estimating equations were conducted on standardised child length and weight outcomes at 12, 18 and 24 months. Results: Non-prescribed substances consisted mostly of tobacco use (77%). Child length and weight were significantly lower in those exposed to the combined use of alcohol and substances compared to no-use and all other use groups (p 0.001), as confirmed by multivariable analyses. Child length and weight were also significantly lower in those exposed to alcohol and/or substance use throughout the antenatal and 1-year postnatal periods, as confirmed by multivariable analyses. Conclusion: Interventions to address the potential long-term adverse effects of combined alcohol and substance use particularly tobacco use, as well as continuous use throughout antenatal and early postnatal periods on subsequent child growth, are needed. Contribution: This study has contributed to the field by showing that combined and continued use of alcohol and other substances during pregnancy and postpartum is associated with impaired early child growth.https://sajp.org.za/index.php/sajp/article/view/2486pregnancyearly postpartuminfant child lengthinfant child weightcombined alcohol and substance use |
| spellingShingle | Yukiko Washio Zugui Zhang Mona Lisa Baishya Marilyn T. Lake Bronwyn Myers Nadia Hoffman Elizabeth Goddard Heather J. Zar Dan J. Stein Petal Petersen Williams Associations of maternal alcohol and non-prescribed substance use with early child growth South African Journal of Psychiatry pregnancy early postpartum infant child length infant child weight combined alcohol and substance use |
| title | Associations of maternal alcohol and non-prescribed substance use with early child growth |
| title_full | Associations of maternal alcohol and non-prescribed substance use with early child growth |
| title_fullStr | Associations of maternal alcohol and non-prescribed substance use with early child growth |
| title_full_unstemmed | Associations of maternal alcohol and non-prescribed substance use with early child growth |
| title_short | Associations of maternal alcohol and non-prescribed substance use with early child growth |
| title_sort | associations of maternal alcohol and non prescribed substance use with early child growth |
| topic | pregnancy early postpartum infant child length infant child weight combined alcohol and substance use |
| url | https://sajp.org.za/index.php/sajp/article/view/2486 |
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