Macroprolactinoma in an adolescent female with primary amenorrhoea
Paediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolactinoma, showing a modest radiological and biochemical response to dop...
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| Language: | English |
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Bioscientifica
2024-12-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
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| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2024/4/EDM-24-0033.xml |
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| author | Ning Zhang Eleanor White Tessa Weir Mark Dexter Winny Varikatt Sarah J Glastras |
| author_facet | Ning Zhang Eleanor White Tessa Weir Mark Dexter Winny Varikatt Sarah J Glastras |
| author_sort | Ning Zhang |
| collection | DOAJ |
| description | Paediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolactinoma, showing a modest radiological and biochemical response to dopamine agonist (DA) therapy. Despite a 10-month duration of increasing DA therapy, initial symptoms of primary amenorrhoea and hyperprolactinaemia persisted, with new symptoms of weight gain, lethargy and low mood. A transsphenoidal resection of the macroprolactinoma was successfully performed, followed by the initiation of additional hormonal therapy. This case explores the unique challenges of treating a macroprolactinoma refractory to medical management in adolescence. |
| format | Article |
| id | doaj-art-234eda4b70aa44e68ce2509778e5e24d |
| institution | OA Journals |
| issn | 2052-0573 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj-art-234eda4b70aa44e68ce2509778e5e24d2025-08-20T02:35:32ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732024-12-012024410.1530/EDM-24-00331Macroprolactinoma in an adolescent female with primary amenorrhoeaNing Zhang0Eleanor White1Tessa Weir2Mark Dexter3Winny Varikatt4Sarah J Glastras5Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, AustraliaDepartment of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, AustraliaNorthern Clinical Medical School, University of Sydney, Sydney, New South Wales, AustraliaNorthern Clinical Medical School, University of Sydney, Sydney, New South Wales, AustraliaNorthern Clinical Medical School, University of Sydney, Sydney, New South Wales, AustraliaDepartment of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, AustraliaPaediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolactinoma, showing a modest radiological and biochemical response to dopamine agonist (DA) therapy. Despite a 10-month duration of increasing DA therapy, initial symptoms of primary amenorrhoea and hyperprolactinaemia persisted, with new symptoms of weight gain, lethargy and low mood. A transsphenoidal resection of the macroprolactinoma was successfully performed, followed by the initiation of additional hormonal therapy. This case explores the unique challenges of treating a macroprolactinoma refractory to medical management in adolescence.https://edm.bioscientifica.com/view/journals/edm/2024/4/EDM-24-0033.xmladolescentmacroprolactinomapituitary |
| spellingShingle | Ning Zhang Eleanor White Tessa Weir Mark Dexter Winny Varikatt Sarah J Glastras Macroprolactinoma in an adolescent female with primary amenorrhoea Endocrinology, Diabetes & Metabolism Case Reports adolescent macroprolactinoma pituitary |
| title | Macroprolactinoma in an adolescent female with primary amenorrhoea |
| title_full | Macroprolactinoma in an adolescent female with primary amenorrhoea |
| title_fullStr | Macroprolactinoma in an adolescent female with primary amenorrhoea |
| title_full_unstemmed | Macroprolactinoma in an adolescent female with primary amenorrhoea |
| title_short | Macroprolactinoma in an adolescent female with primary amenorrhoea |
| title_sort | macroprolactinoma in an adolescent female with primary amenorrhoea |
| topic | adolescent macroprolactinoma pituitary |
| url | https://edm.bioscientifica.com/view/journals/edm/2024/4/EDM-24-0033.xml |
| work_keys_str_mv | AT ningzhang macroprolactinomainanadolescentfemalewithprimaryamenorrhoea AT eleanorwhite macroprolactinomainanadolescentfemalewithprimaryamenorrhoea AT tessaweir macroprolactinomainanadolescentfemalewithprimaryamenorrhoea AT markdexter macroprolactinomainanadolescentfemalewithprimaryamenorrhoea AT winnyvarikatt macroprolactinomainanadolescentfemalewithprimaryamenorrhoea AT sarahjglastras macroprolactinomainanadolescentfemalewithprimaryamenorrhoea |