COVID-19 in children across three Asian cosmopolitan regions
As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, C...
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| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1846462 |
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| author | Gilbert T. Chua Xiaoli Xiong Eun Hwa Choi Mi Seon Han Sung Hee Chang Byoung Lo Jin Eun Joo Lee Baek Nam Kim Min Kyoung Kim Kihyun Doo Ju Hee Seo Yae Jean Kim Yeo Jin Kim Ji Young Park Sun Bok Suh Hyunju Lee Eun Young Cho Dong Hyun Kim Jong Min Kim Hye Young Kim Su Eun Park Joon Kee Lee Dae Sun Jo Seung Man Cho Jae Hong Choi Kyo Jin Jo Young June Choe Ki Hwan Kim Shuiqing Chi Shao-tao Tang Huan Qin Li Shan Zhou Peng Chen Joshua Sung Chih Wong Kate Ching Ching Chan Felix Yat Sun Yau Shu Yan Lam Calvin Chit Kwong Chow Tak Wai Wong Victor Chi-man Chan Grace Wing Kit Poon Chun Bong Chow Wilfred H. S. Wong Yu Lung Lau Godfrey Chi Fung Chan Celine S. L. Chui Xue Li Marco Hok Kung Ho Ian C. K. Wong Paul Kwong Hang Tam Kelvin K. W. To Jong Hyun Kim Patrick Ip Mike Yat Wah Kwan |
| author_facet | Gilbert T. Chua Xiaoli Xiong Eun Hwa Choi Mi Seon Han Sung Hee Chang Byoung Lo Jin Eun Joo Lee Baek Nam Kim Min Kyoung Kim Kihyun Doo Ju Hee Seo Yae Jean Kim Yeo Jin Kim Ji Young Park Sun Bok Suh Hyunju Lee Eun Young Cho Dong Hyun Kim Jong Min Kim Hye Young Kim Su Eun Park Joon Kee Lee Dae Sun Jo Seung Man Cho Jae Hong Choi Kyo Jin Jo Young June Choe Ki Hwan Kim Shuiqing Chi Shao-tao Tang Huan Qin Li Shan Zhou Peng Chen Joshua Sung Chih Wong Kate Ching Ching Chan Felix Yat Sun Yau Shu Yan Lam Calvin Chit Kwong Chow Tak Wai Wong Victor Chi-man Chan Grace Wing Kit Poon Chun Bong Chow Wilfred H. S. Wong Yu Lung Lau Godfrey Chi Fung Chan Celine S. L. Chui Xue Li Marco Hok Kung Ho Ian C. K. Wong Paul Kwong Hang Tam Kelvin K. W. To Jong Hyun Kim Patrick Ip Mike Yat Wah Kwan |
| author_sort | Gilbert T. Chua |
| collection | DOAJ |
| description | As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p < 0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p < 0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p < 0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p < 0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p=0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin (p = 0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age. |
| format | Article |
| id | doaj-art-234c038c01cc4ee1ab8ce4f4e9135681 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-234c038c01cc4ee1ab8ce4f4e91356812025-08-20T02:12:20ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01912588259610.1080/22221751.2020.1846462COVID-19 in children across three Asian cosmopolitan regionsGilbert T. Chua0Xiaoli Xiong1Eun Hwa Choi2Mi Seon Han3Sung Hee Chang4Byoung Lo Jin5Eun Joo Lee6Baek Nam Kim7Min Kyoung Kim8Kihyun Doo9Ju Hee Seo10Yae Jean Kim11Yeo Jin Kim12Ji Young Park13Sun Bok Suh14Hyunju Lee15Eun Young Cho16Dong Hyun Kim17Jong Min Kim18Hye Young Kim19Su Eun Park20Joon Kee Lee21Dae Sun Jo22Seung Man Cho23Jae Hong Choi24Kyo Jin Jo25Young June Choe26Ki Hwan Kim27Shuiqing Chi28Shao-tao Tang29Huan Qin30Li Shan Zhou31Peng Chen32Joshua Sung Chih Wong33Kate Ching Ching Chan34Felix Yat Sun Yau35Shu Yan Lam36Calvin Chit Kwong Chow37Tak Wai Wong38Victor Chi-man Chan39Grace Wing Kit Poon40Chun Bong Chow41Wilfred H. S. Wong42Yu Lung Lau43Godfrey Chi Fung Chan44Celine S. L. Chui45Xue Li46Marco Hok Kung Ho47Ian C. K. Wong48Paul Kwong Hang Tam49Kelvin K. W. To50Jong Hyun Kim51Patrick Ip52Mike Yat Wah Kwan53Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Integrated Chinese and Western Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, KoreaDepartment of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, KoreaDepartment of Pediatrics, Seoul Medical Center, Seoul, KoreaDepartment of Pediatrics, Hongseong Medical Center, Hongseong, KoreaDepartment of Pediatrics, Seongnam Citizens Medical Center, Seongnam, KoreaDepartment of Pediatrics, Gyeonggi Provincial Medical Center Ansung Hospital, Ansung, KoreaDepartment of Pediatrics, Seonam Hospital, Seoul, KoreaDepartment of Pediatrics, Gyeonggi Provincial Medical Center Icheon Hospital, Icheon, KoreaDepartment of Pediatrics, Dankook University Hospital, Cheonan, KoreaDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Pediatrics, Masan Medical Center, Changwon, KoreaDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, KoreaDepartment of Pediatrics, Busan Medical Center, Busan, KoreaDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Pediatrics, Chungnam National University Hospital, Daejeon, KoreaDepartment of Pediatrics, Inha University Hospital, Incheon, KoreaDepartment of Pediatrics, Myongji Hospital, Goyang, KoreaDepartment of Pediatrics, Pusan National University Hospital, Busan, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Yangsan, KoreaDepartment of Pediatrics, Chungbuk National University Hospital, Cheongju, KoreaDepartment of Pediatrics, Jeonbuk National University Medical School, Jeonju, KoreaDepartment of Pediatrics, Dongguk University College of Medicine, Gyeongju, KoreaDepartment of Pediatrics, Jeju National University Hospital, Jeju, KoreaDepartment of Pediatrics, Pusan National University Children’s Hospital, Yangsan, KoreaDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Pediatrics, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, KoreaDepartment of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaDepartment of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaInstitute of Maternal and Child Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaDepartment of Integrated Chinese and Western Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaDepartment of Respiratory Medicine, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, Tuen Mun Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, Pamela Youle Nethersole Eastern Hospital, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDivision of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Pediatrics, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, KoreaDepartment of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, People’s Republic of ChinaDepartment of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, People’s Republic of ChinaAs another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p < 0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p < 0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p < 0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p < 0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p=0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin (p = 0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age.https://www.tandfonline.com/doi/10.1080/22221751.2020.1846462COVID-19Asiachildrentravel historyage-stratified |
| spellingShingle | Gilbert T. Chua Xiaoli Xiong Eun Hwa Choi Mi Seon Han Sung Hee Chang Byoung Lo Jin Eun Joo Lee Baek Nam Kim Min Kyoung Kim Kihyun Doo Ju Hee Seo Yae Jean Kim Yeo Jin Kim Ji Young Park Sun Bok Suh Hyunju Lee Eun Young Cho Dong Hyun Kim Jong Min Kim Hye Young Kim Su Eun Park Joon Kee Lee Dae Sun Jo Seung Man Cho Jae Hong Choi Kyo Jin Jo Young June Choe Ki Hwan Kim Shuiqing Chi Shao-tao Tang Huan Qin Li Shan Zhou Peng Chen Joshua Sung Chih Wong Kate Ching Ching Chan Felix Yat Sun Yau Shu Yan Lam Calvin Chit Kwong Chow Tak Wai Wong Victor Chi-man Chan Grace Wing Kit Poon Chun Bong Chow Wilfred H. S. Wong Yu Lung Lau Godfrey Chi Fung Chan Celine S. L. Chui Xue Li Marco Hok Kung Ho Ian C. K. Wong Paul Kwong Hang Tam Kelvin K. W. To Jong Hyun Kim Patrick Ip Mike Yat Wah Kwan COVID-19 in children across three Asian cosmopolitan regions Emerging Microbes and Infections COVID-19 Asia children travel history age-stratified |
| title | COVID-19 in children across three Asian cosmopolitan regions |
| title_full | COVID-19 in children across three Asian cosmopolitan regions |
| title_fullStr | COVID-19 in children across three Asian cosmopolitan regions |
| title_full_unstemmed | COVID-19 in children across three Asian cosmopolitan regions |
| title_short | COVID-19 in children across three Asian cosmopolitan regions |
| title_sort | covid 19 in children across three asian cosmopolitan regions |
| topic | COVID-19 Asia children travel history age-stratified |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1846462 |
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