PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION
The aim of the study. Comparative analysis of the risk assessment of thromboembolism by CHADS2 and CHA2DS2-VASc scores, and to study the preventive effectiveness of different antithrombotic agents in patients with long-lasting аtrial fibrillation (AF) at 1 year follow-up. Materials and methods. The...
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InterMedservice
2014-03-01
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| Series: | Евразийский Кардиологический Журнал |
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| Online Access: | https://www.heartj.asia/jour/article/view/5561 |
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| author | R. D. Kurbanov N. J. Zakirov D. B. Irisov Sh. S. Khusanov |
| author_facet | R. D. Kurbanov N. J. Zakirov D. B. Irisov Sh. S. Khusanov |
| author_sort | R. D. Kurbanov |
| collection | DOAJ |
| description | The aim of the study. Comparative analysis of the risk assessment of thromboembolism by CHADS2 and CHA2DS2-VASc scores, and to study the preventive effectiveness of different antithrombotic agents in patients with long-lasting аtrial fibrillation (AF) at 1 year follow-up. Materials and methods. The study included 108 patients aged 38 to 78 years old (mean age 62,6±8,4 years) with persistent or permanent AF. In 93.5% of patients revealed coronary artery disease and / or arterial hypertension, in 6.5% - non-coronary heart diseases. The risk of tromboembolism assessed by CHADS2 and CHA2DS2-VASc scores. Results. Patients at low risk of tromboembolism, according to CHADS2 score was 2.8%, in their absence, on a CHA2DS2-VASc score. Patients with moderate risk of tromboembolism, in these scores were 63.9% and 7,4% (χ2=72.653; p=0.000) respectively, and a high risk of tromboembolism - 33,3% and 92,6% (χ2=78,796, p=0.000) respectively. Depending on the ways to prevent tromboembolism, patients were divided into 2 groups. 1st group included patients treated with warfarin (n=90), and the endpoints were observed in 5.6% of patients. 2nd group included patients (n=18) treated with acetylsalicylic acid (ASA) and the end point was observed in 27.8% of patients. Conclusion. The introduction of a new CHA2DS2-VASc score led to an increase number of patients, who need mandatory anticoagulant therapy by 2.8 times. In the group of patients with atrial fibrillation treated with warfarin compared with a group of patients treated with aspirin, where cases of ischemic stroke have developed less often, and their clinical manifestation are less pronounced and are characterized by a benign course. |
| format | Article |
| id | doaj-art-2344da3c9ef14f82912d3aac673fb3c8 |
| institution | DOAJ |
| issn | 2225-1685 2305-0748 |
| language | Russian |
| publishDate | 2014-03-01 |
| publisher | InterMedservice |
| record_format | Article |
| series | Евразийский Кардиологический Журнал |
| spelling | doaj-art-2344da3c9ef14f82912d3aac673fb3c82025-08-20T02:53:47ZrusInterMedserviceЕвразийский Кардиологический Журнал2225-16852305-07482014-03-0101909410.38109/2225-1685-2014-1-90-945558PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATIONR. D. Kurbanov0N. J. Zakirov1D. B. Irisov2Sh. S. Khusanov3Republican Specialized Center of CardiologyRepublican Specialized Center of CardiologyRepublican Specialized Center of CardiologyRepublican Specialized Center of CardiologyThe aim of the study. Comparative analysis of the risk assessment of thromboembolism by CHADS2 and CHA2DS2-VASc scores, and to study the preventive effectiveness of different antithrombotic agents in patients with long-lasting аtrial fibrillation (AF) at 1 year follow-up. Materials and methods. The study included 108 patients aged 38 to 78 years old (mean age 62,6±8,4 years) with persistent or permanent AF. In 93.5% of patients revealed coronary artery disease and / or arterial hypertension, in 6.5% - non-coronary heart diseases. The risk of tromboembolism assessed by CHADS2 and CHA2DS2-VASc scores. Results. Patients at low risk of tromboembolism, according to CHADS2 score was 2.8%, in their absence, on a CHA2DS2-VASc score. Patients with moderate risk of tromboembolism, in these scores were 63.9% and 7,4% (χ2=72.653; p=0.000) respectively, and a high risk of tromboembolism - 33,3% and 92,6% (χ2=78,796, p=0.000) respectively. Depending on the ways to prevent tromboembolism, patients were divided into 2 groups. 1st group included patients treated with warfarin (n=90), and the endpoints were observed in 5.6% of patients. 2nd group included patients (n=18) treated with acetylsalicylic acid (ASA) and the end point was observed in 27.8% of patients. Conclusion. The introduction of a new CHA2DS2-VASc score led to an increase number of patients, who need mandatory anticoagulant therapy by 2.8 times. In the group of patients with atrial fibrillation treated with warfarin compared with a group of patients treated with aspirin, where cases of ischemic stroke have developed less often, and their clinical manifestation are less pronounced and are characterized by a benign course.https://www.heartj.asia/jour/article/view/5561фибрилляция предсердийтромбоэмболические осложненияchads2cha2ds2-vascварфаринацетилсалициловая кислотаatrial fibrillationthromboembolismchads2cha2ds2-vasc warfarinacetylsalicylic acid |
| spellingShingle | R. D. Kurbanov N. J. Zakirov D. B. Irisov Sh. S. Khusanov PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION Евразийский Кардиологический Журнал фибрилляция предсердий тромбоэмболические осложнения chads2 cha2ds2-vasc варфарин ацетилсалициловая кислота atrial fibrillation thromboembolism chads2 cha2ds2-vasc warfarin acetylsalicylic acid |
| title | PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION |
| title_full | PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION |
| title_fullStr | PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION |
| title_full_unstemmed | PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION |
| title_short | PREDICTION OF THROMBOEMBOLISM IN PATIENTS WITH LONG-LASTING ATRIAL FIBRILLATION |
| title_sort | prediction of thromboembolism in patients with long lasting atrial fibrillation |
| topic | фибрилляция предсердий тромбоэмболические осложнения chads2 cha2ds2-vasc варфарин ацетилсалициловая кислота atrial fibrillation thromboembolism chads2 cha2ds2-vasc warfarin acetylsalicylic acid |
| url | https://www.heartj.asia/jour/article/view/5561 |
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