Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis
BackgroundKawasaki Disease (KD) is an acute vasculitis primarily affecting children, with intravenous immunoglobulin (IVIG) being the standard treatment and leading to increased risk of coronary artery abnormalities.ObjectiveThis systematic review and meta-analysis aim to evaluate the prevalence of...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1566590/full |
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| author | Shuting Zou Bingyu Hu |
| author_facet | Shuting Zou Bingyu Hu |
| author_sort | Shuting Zou |
| collection | DOAJ |
| description | BackgroundKawasaki Disease (KD) is an acute vasculitis primarily affecting children, with intravenous immunoglobulin (IVIG) being the standard treatment and leading to increased risk of coronary artery abnormalities.ObjectiveThis systematic review and meta-analysis aim to evaluate the prevalence of IVIG resistance in KD and identify potential predictors and outcomes associated with this resistance.MethodsA comprehensive search of PubMed, Medline, Embase, and other relevant databases was conducted to identify studies reporting IVIG resistance in KD patients. Data on prevalence rates, patient demographics, and associated factors were extracted and analyzed.ResultsThe analysis included 26 studies with a total of 46,461 patients. The overall prevalence of IVIG resistance was found to be 14% (95% CI: 12%–16%), and The prevalence among males and females was 9% (95% CI; 7% to 10%) and 4% (95% CI; 3.7% to 4.3%), respectively.ConclusionIVIG resistance remains a significant challenge in the management of KD. Identifying patients at higher risk for IVIG resistance and developing alternative treatment strategies are crucial for improving outcomes in this population. |
| format | Article |
| id | doaj-art-233937cd0e294604ab4e775c6a64caf2 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-233937cd0e294604ab4e775c6a64caf22025-08-20T03:29:31ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.15665901566590Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysisShuting ZouBingyu HuBackgroundKawasaki Disease (KD) is an acute vasculitis primarily affecting children, with intravenous immunoglobulin (IVIG) being the standard treatment and leading to increased risk of coronary artery abnormalities.ObjectiveThis systematic review and meta-analysis aim to evaluate the prevalence of IVIG resistance in KD and identify potential predictors and outcomes associated with this resistance.MethodsA comprehensive search of PubMed, Medline, Embase, and other relevant databases was conducted to identify studies reporting IVIG resistance in KD patients. Data on prevalence rates, patient demographics, and associated factors were extracted and analyzed.ResultsThe analysis included 26 studies with a total of 46,461 patients. The overall prevalence of IVIG resistance was found to be 14% (95% CI: 12%–16%), and The prevalence among males and females was 9% (95% CI; 7% to 10%) and 4% (95% CI; 3.7% to 4.3%), respectively.ConclusionIVIG resistance remains a significant challenge in the management of KD. Identifying patients at higher risk for IVIG resistance and developing alternative treatment strategies are crucial for improving outcomes in this population.https://www.frontiersin.org/articles/10.3389/fped.2025.1566590/fullKawasaki diseaseIVIG resistanceprevalencerisk factorsrandomized controlled trialsclinical outcomes |
| spellingShingle | Shuting Zou Bingyu Hu Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis Frontiers in Pediatrics Kawasaki disease IVIG resistance prevalence risk factors randomized controlled trials clinical outcomes |
| title | Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis |
| title_full | Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis |
| title_fullStr | Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis |
| title_short | Prevalence of IVIG resistance in Kawasaki disease: a systematic review and meta-analysis |
| title_sort | prevalence of ivig resistance in kawasaki disease a systematic review and meta analysis |
| topic | Kawasaki disease IVIG resistance prevalence risk factors randomized controlled trials clinical outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1566590/full |
| work_keys_str_mv | AT shutingzou prevalenceofivigresistanceinkawasakidiseaseasystematicreviewandmetaanalysis AT bingyuhu prevalenceofivigresistanceinkawasakidiseaseasystematicreviewandmetaanalysis |