Resting-state brain and spinal cord networks in humans are functionally integrated.
In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique sc...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-07-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000789&type=printable |
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| author | Shahabeddin Vahdat Ali Khatibi Ovidiu Lungu Jürgen Finsterbusch Christian Büchel Julien Cohen-Adad Veronique Marchand-Pauvert Julien Doyon |
| author_facet | Shahabeddin Vahdat Ali Khatibi Ovidiu Lungu Jürgen Finsterbusch Christian Büchel Julien Cohen-Adad Veronique Marchand-Pauvert Julien Doyon |
| author_sort | Shahabeddin Vahdat |
| collection | DOAJ |
| description | In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest. |
| format | Article |
| id | doaj-art-2334fc6f37574f65a6679541fbff1d1a |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-2334fc6f37574f65a6679541fbff1d1a2025-08-20T02:55:20ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852020-07-01187e300078910.1371/journal.pbio.3000789Resting-state brain and spinal cord networks in humans are functionally integrated.Shahabeddin VahdatAli KhatibiOvidiu LunguJürgen FinsterbuschChristian BüchelJulien Cohen-AdadVeronique Marchand-PauvertJulien DoyonIn the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000789&type=printable |
| spellingShingle | Shahabeddin Vahdat Ali Khatibi Ovidiu Lungu Jürgen Finsterbusch Christian Büchel Julien Cohen-Adad Veronique Marchand-Pauvert Julien Doyon Resting-state brain and spinal cord networks in humans are functionally integrated. PLoS Biology |
| title | Resting-state brain and spinal cord networks in humans are functionally integrated. |
| title_full | Resting-state brain and spinal cord networks in humans are functionally integrated. |
| title_fullStr | Resting-state brain and spinal cord networks in humans are functionally integrated. |
| title_full_unstemmed | Resting-state brain and spinal cord networks in humans are functionally integrated. |
| title_short | Resting-state brain and spinal cord networks in humans are functionally integrated. |
| title_sort | resting state brain and spinal cord networks in humans are functionally integrated |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3000789&type=printable |
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