Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms
Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. We used resting-state functional magnetic resonance imaging to explore the intrinsic coupling patterns between the amplitude and synchronisation o...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/1672708 |
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| author | Xiaozheng Liu Jiuzun Chen Bangli Shen Gang Wang Jiapeng Li Hongtao Hou Xingli Chen Zhongwei Guo Chuanwan Mao |
| author_facet | Xiaozheng Liu Jiuzun Chen Bangli Shen Gang Wang Jiapeng Li Hongtao Hou Xingli Chen Zhongwei Guo Chuanwan Mao |
| author_sort | Xiaozheng Liu |
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| description | Neuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. We used resting-state functional magnetic resonance imaging to explore the intrinsic coupling patterns between the amplitude and synchronisation of low-frequency brain fluctuations using the amplitude of low-frequency fluctuations (ALFF) and the functional connectivity density (FCD) in 16 patients who had mild cognitive impairment with depressive symptoms (D-MCI) (mean age: 69.6 ± 6.2 years) and 18 patients with nondepressed mild cognitive impairment (nD-MCI) (mean age: 72.1 ± 9.7 years). Coupling was quantified as the correlations between the ALFF values and their associated FCDs. The results showed that the ALFF values in the D-MCI group were higher in the left medial prefrontal cortex (mPFC) and lower in the right precentral gyrus (preCG), and the FCD values were higher in the left medial temporal gyrus (MTG) than those in the nD-MCI group. Further, correlation analyses demonstrated that, in the D-MCI group, the mPFC was negatively correlated with the MTG. These findings may relate to the characteristics of mood disorders in patients with MCI, and they offer further insight into the neuropathophysiology of MCI with depressive symptoms. |
| format | Article |
| id | doaj-art-233452b8a0b2468492a1c9a42afeac9c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-233452b8a0b2468492a1c9a42afeac9c2025-02-03T01:10:22ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/16727081672708Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive SymptomsXiaozheng Liu0Jiuzun Chen1Bangli Shen2Gang Wang3Jiapeng Li4Hongtao Hou5Xingli Chen6Zhongwei Guo7Chuanwan Mao8Department of Radiology, China-USA Neuroimaging Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Radiology, China-USA Neuroimaging Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Radiology, China-USA Neuroimaging Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaTongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, ChinaDepartment of Radiology, China-USA Neuroimaging Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaNeuroimaging studies have demonstrated that major depressive disorder increases the risk of dementia in older individuals with mild cognitive impairment. We used resting-state functional magnetic resonance imaging to explore the intrinsic coupling patterns between the amplitude and synchronisation of low-frequency brain fluctuations using the amplitude of low-frequency fluctuations (ALFF) and the functional connectivity density (FCD) in 16 patients who had mild cognitive impairment with depressive symptoms (D-MCI) (mean age: 69.6 ± 6.2 years) and 18 patients with nondepressed mild cognitive impairment (nD-MCI) (mean age: 72.1 ± 9.7 years). Coupling was quantified as the correlations between the ALFF values and their associated FCDs. The results showed that the ALFF values in the D-MCI group were higher in the left medial prefrontal cortex (mPFC) and lower in the right precentral gyrus (preCG), and the FCD values were higher in the left medial temporal gyrus (MTG) than those in the nD-MCI group. Further, correlation analyses demonstrated that, in the D-MCI group, the mPFC was negatively correlated with the MTG. These findings may relate to the characteristics of mood disorders in patients with MCI, and they offer further insight into the neuropathophysiology of MCI with depressive symptoms.http://dx.doi.org/10.1155/2018/1672708 |
| spellingShingle | Xiaozheng Liu Jiuzun Chen Bangli Shen Gang Wang Jiapeng Li Hongtao Hou Xingli Chen Zhongwei Guo Chuanwan Mao Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms Neural Plasticity |
| title | Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms |
| title_full | Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms |
| title_fullStr | Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms |
| title_full_unstemmed | Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms |
| title_short | Altered Intrinsic Coupling between Functional Connectivity Density and Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment with Depressive Symptoms |
| title_sort | altered intrinsic coupling between functional connectivity density and amplitude of low frequency fluctuation in mild cognitive impairment with depressive symptoms |
| url | http://dx.doi.org/10.1155/2018/1672708 |
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