Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study
Objective. This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method. A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last foll...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/3458356 |
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| author | Junqing Wang Huanfen Zhou Limin Qin Chunxia Peng Jie Zhao Da Teng Dahe Lin Nanping Ai Quangang Xu Shihui Wei |
| author_facet | Junqing Wang Huanfen Zhou Limin Qin Chunxia Peng Jie Zhao Da Teng Dahe Lin Nanping Ai Quangang Xu Shihui Wei |
| author_sort | Junqing Wang |
| collection | DOAJ |
| description | Objective. This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method. A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45–65 years and age ≥ 65 years). Results. 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45–83 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA) < 20/200 in 93% and final BCVA < 20/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (≥65 years) developed NMOSD or MS. Conclusion. Chinese patients in the age group ≥ 65 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery. |
| format | Article |
| id | doaj-art-23258742a7bf436a9360df5b9052eed9 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-23258742a7bf436a9360df5b9052eed92025-02-03T01:22:55ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/34583563458356Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up StudyJunqing Wang0Huanfen Zhou1Limin Qin2Chunxia Peng3Jie Zhao4Da Teng5Dahe Lin6Nanping Ai7Quangang Xu8Shihui Wei9Department of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaDepartment of Ophthalmology, Chinese PLA General Hospital, Beijing, ChinaObjective. This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method. A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45–65 years and age ≥ 65 years). Results. 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45–83 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA) < 20/200 in 93% and final BCVA < 20/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (≥65 years) developed NMOSD or MS. Conclusion. Chinese patients in the age group ≥ 65 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery.http://dx.doi.org/10.1155/2017/3458356 |
| spellingShingle | Junqing Wang Huanfen Zhou Limin Qin Chunxia Peng Jie Zhao Da Teng Dahe Lin Nanping Ai Quangang Xu Shihui Wei Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study Journal of Ophthalmology |
| title | Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study |
| title_full | Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study |
| title_fullStr | Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study |
| title_full_unstemmed | Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study |
| title_short | Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study |
| title_sort | optic neuritis in the older chinese population a 5 year follow up study |
| url | http://dx.doi.org/10.1155/2017/3458356 |
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