A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity
Abstract Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, perica...
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BMC
2024-12-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-024-01322-z |
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| author | Hadi Zare-Zardini Mohammad-Taghi Hedayati-Goudarzi Ameneh Alizadeh Fatemeh Sadeghian-Nodoushan Hossein Soltaninejad |
| author_facet | Hadi Zare-Zardini Mohammad-Taghi Hedayati-Goudarzi Ameneh Alizadeh Fatemeh Sadeghian-Nodoushan Hossein Soltaninejad |
| author_sort | Hadi Zare-Zardini |
| collection | DOAJ |
| description | Abstract Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial complications, and vascular toxicity. Strategies to mitigate chemotherapy-induced cardiotoxicity may include the use of cardioprotective agents (e.g., dexrazoxane), dose adjustments, alternative treatment regimens, and the implementation of preventive measures, such as lifestyle modifications and the management of cardiovascular risk factors. Ginsenosides, the active compounds found in ginseng (Panax ginseng), have been studied for their potential cardioprotective effects in the context of chemotherapy-induced cardiotoxicity. In this review, we investigate the cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity. Ginsenosides have been shown to possess potent antioxidant properties, which can help mitigate the oxidative stress and inflammation associated with chemotherapy-induced cardiac injury. They can modulate the expression of antioxidant enzymes and reduce the production of reactive oxygen species, thereby protecting cardiomyocytes from damage. Ginsenosides can also inhibit apoptosis (programmed cell death) of cardiomyocytes, which is a key mechanism underlying chemotherapy-induced cardiotoxicity. Modulation of ion channels, improvement of lipid profiles, anti-platelet and anti-thrombotic effects, and promotion of angiogenesis and neovascularization are another important mechanisms behind potential effects of ginsenosides on cardiovascular health. Ginsenosides can improve various parameters of cardiac function, such as ejection fraction, fractional shortening, and cardiac output, in animal models of chemotherapy-induced cardiotoxicity. The cardioprotective effects of ginsenosides have been observed in preclinical studies using various chemotherapeutic agents, including doxorubicin, cisplatin, and 5-fluorouracil. However, more clinical studies are needed to fully elucidate the therapeutic potential of ginsenosides in preventing and managing chemotherapy-induced cardiotoxicity in cancer patients. |
| format | Article |
| id | doaj-art-2323b4e1bd8d47fbb57719dc96eb1f88 |
| institution | OA Journals |
| issn | 1475-925X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj-art-2323b4e1bd8d47fbb57719dc96eb1f882025-08-20T01:57:16ZengBMCBioMedical Engineering OnLine1475-925X2024-12-0123112410.1186/s12938-024-01322-zA review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicityHadi Zare-Zardini0Mohammad-Taghi Hedayati-Goudarzi1Ameneh Alizadeh2Fatemeh Sadeghian-Nodoushan3Hossein Soltaninejad4Department of Biomedical Engineering, Meybod UniversityDepartment of Cardiology, School of Medicine, Rouhani Hospital, Babol University of Medical SciencesDepartment of Applied Chemistry, Faculty of Gas and Petroleum, Yasouj UniversityBiotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical SciencesDepartment of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares UniversityAbstract Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This can lead to a range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial complications, and vascular toxicity. Strategies to mitigate chemotherapy-induced cardiotoxicity may include the use of cardioprotective agents (e.g., dexrazoxane), dose adjustments, alternative treatment regimens, and the implementation of preventive measures, such as lifestyle modifications and the management of cardiovascular risk factors. Ginsenosides, the active compounds found in ginseng (Panax ginseng), have been studied for their potential cardioprotective effects in the context of chemotherapy-induced cardiotoxicity. In this review, we investigate the cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity. Ginsenosides have been shown to possess potent antioxidant properties, which can help mitigate the oxidative stress and inflammation associated with chemotherapy-induced cardiac injury. They can modulate the expression of antioxidant enzymes and reduce the production of reactive oxygen species, thereby protecting cardiomyocytes from damage. Ginsenosides can also inhibit apoptosis (programmed cell death) of cardiomyocytes, which is a key mechanism underlying chemotherapy-induced cardiotoxicity. Modulation of ion channels, improvement of lipid profiles, anti-platelet and anti-thrombotic effects, and promotion of angiogenesis and neovascularization are another important mechanisms behind potential effects of ginsenosides on cardiovascular health. Ginsenosides can improve various parameters of cardiac function, such as ejection fraction, fractional shortening, and cardiac output, in animal models of chemotherapy-induced cardiotoxicity. The cardioprotective effects of ginsenosides have been observed in preclinical studies using various chemotherapeutic agents, including doxorubicin, cisplatin, and 5-fluorouracil. However, more clinical studies are needed to fully elucidate the therapeutic potential of ginsenosides in preventing and managing chemotherapy-induced cardiotoxicity in cancer patients.https://doi.org/10.1186/s12938-024-01322-zGinsenosideGinsengCardiotoxicityChemotherapyCardioprotective |
| spellingShingle | Hadi Zare-Zardini Mohammad-Taghi Hedayati-Goudarzi Ameneh Alizadeh Fatemeh Sadeghian-Nodoushan Hossein Soltaninejad A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity BioMedical Engineering OnLine Ginsenoside Ginseng Cardiotoxicity Chemotherapy Cardioprotective |
| title | A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity |
| title_full | A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity |
| title_fullStr | A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity |
| title_full_unstemmed | A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity |
| title_short | A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity |
| title_sort | review of cardioprotective effect of ginsenosides in chemotherapy induced cardiotoxicity |
| topic | Ginsenoside Ginseng Cardiotoxicity Chemotherapy Cardioprotective |
| url | https://doi.org/10.1186/s12938-024-01322-z |
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