Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression
The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), whi...
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| Language: | English |
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BioMed Central
2019-11-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-4-e36.pdf |
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| author | Danbi Seo Dain Kim Wanyeon Kim |
| author_facet | Danbi Seo Dain Kim Wanyeon Kim |
| author_sort | Danbi Seo |
| collection | DOAJ |
| description | The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers. |
| format | Article |
| id | doaj-art-231f4a5a173c4e9c91ebaa23bb5a7131 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-231f4a5a173c4e9c91ebaa23bb5a71312025-02-02T02:25:34ZengBioMed CentralGenomics & Informatics2234-07422019-11-0117410.5808/GI.2019.17.4.e36580Long non-coding RNA linc00152 acting as a promising oncogene in cancer progressionDanbi Seo0Dain Kim1Wanyeon Kim2 Department of Science Education, Korea National University of Education, Cheongju 28173, Korea Department of Science Education, Korea National University of Education, Cheongju 28173, Korea Department of Science Education, Korea National University of Education, Cheongju 28173, KoreaThe incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.http://genominfo.org/upload/pdf/gi-2019-17-4-e36.pdflinc00152long non-coding rnaoncogenetumorigenesis |
| spellingShingle | Danbi Seo Dain Kim Wanyeon Kim Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression Genomics & Informatics linc00152 long non-coding rna oncogene tumorigenesis |
| title | Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression |
| title_full | Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression |
| title_fullStr | Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression |
| title_full_unstemmed | Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression |
| title_short | Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression |
| title_sort | long non coding rna linc00152 acting as a promising oncogene in cancer progression |
| topic | linc00152 long non-coding rna oncogene tumorigenesis |
| url | http://genominfo.org/upload/pdf/gi-2019-17-4-e36.pdf |
| work_keys_str_mv | AT danbiseo longnoncodingrnalinc00152actingasapromisingoncogeneincancerprogression AT dainkim longnoncodingrnalinc00152actingasapromisingoncogeneincancerprogression AT wanyeonkim longnoncodingrnalinc00152actingasapromisingoncogeneincancerprogression |