Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions

Introduction: Magnified dermoscopy (MD), or optical super-high magnification dermoscopy is an emerging technique in dermatology. Objectives: The study aims to evaluate the distribution of conventional dermoscopy, MD, and reflectance confocal microscopy (RCM) features in dermoscopically equivocal...

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Main Authors: Stefania Guida, Silvana Ciardo, Shaniko Kaleci, Francesca Farnetani, Marco Spadafora, Giulia Radi, Renato Rossi, Elisa Molinelli, Sabrina Longhitano, Claudio Conforti, Carmen Cantisani, Camilla Chello, Oriana Simonetti, Anna Maria Offidani, Pietro Rubegni, Franco Rongioletti, Caterina Longo, Elisa Cinotti, Giovanni Pellacani
Format: Article
Language:English
Published: Mattioli1885 2025-07-01
Series:Dermatology Practical & Conceptual
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Online Access:https://dpcj.org/index.php/dpc/article/view/5253
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author Stefania Guida
Silvana Ciardo
Shaniko Kaleci
Francesca Farnetani
Marco Spadafora
Giulia Radi
Renato Rossi
Elisa Molinelli
Sabrina Longhitano
Claudio Conforti
Carmen Cantisani
Camilla Chello
Oriana Simonetti
Anna Maria Offidani
Pietro Rubegni
Franco Rongioletti
Caterina Longo
Elisa Cinotti
Giovanni Pellacani
author_facet Stefania Guida
Silvana Ciardo
Shaniko Kaleci
Francesca Farnetani
Marco Spadafora
Giulia Radi
Renato Rossi
Elisa Molinelli
Sabrina Longhitano
Claudio Conforti
Carmen Cantisani
Camilla Chello
Oriana Simonetti
Anna Maria Offidani
Pietro Rubegni
Franco Rongioletti
Caterina Longo
Elisa Cinotti
Giovanni Pellacani
author_sort Stefania Guida
collection DOAJ
description Introduction: Magnified dermoscopy (MD), or optical super-high magnification dermoscopy is an emerging technique in dermatology. Objectives: The study aims to evaluate the distribution of conventional dermoscopy, MD, and reflectance confocal microscopy (RCM) features in dermoscopically equivocal pigmented lesions and to estimate their diagnostic accuracy. Methods :A retrospective analysis of conventional dermoscopic (´20), MD (´400) and RCM  pictures of dermoscopically equivocal pigmented lesions, diagnosed as either nevi or melanoma, was performed. Distribution of features, sensitivity, and specificity for dermoscopy, MD, RCM and a combination of these last 2 with conventional dermoscopy were estimated. Results: A total of 74 nevi and 20 melanomas were included in the analysis. A positive correlation was observed between a 7-point checklist in conventional dermoscopy and the diagnosis of melanoma. With MD, a significant correlation between dots, non-edged papillae, and melanoma was observed, but the technique did not significantly impact diagnostic accuracy as compared to traditional dermoscopy. On the other hand, RCM, alone or in combimation with traditional dermoscopy, iincreased diagnostic accuracy, in particular, specificity for melanoma diagnosis. Conclusions: RCM has a defined role in increasing diagnostic accuracy of doubtful dermoscopic lesions while the role of MD in clinical practice has yet to be defined and methodologic standardization as well as a revision of terminology is encouraged to improve the recognition of features.
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spelling doaj-art-2312b6842c974686af04f821e07d3e212025-08-20T03:06:20ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-07-0115310.5826/dpc.1503a5253Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesionsStefania Guida0https://orcid.org/0000-0002-8221-6694Silvana Ciardo1Shaniko Kaleci2Francesca Farnetani3Marco Spadafora4Giulia Radi5Renato Rossi6Elisa Molinelli7Sabrina Longhitano8Claudio Conforti9Carmen Cantisani10Camilla Chello11Oriana Simonetti12Anna Maria Offidani13Pietro Rubegni14Franco Rongioletti15Caterina Longo16Elisa Cinotti17Giovanni Pellacani18Dermatology Clinic Vita Salute San Raffaele University Milano, ItalyDermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, ItalyDermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, ItalyDermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, ItalyAzienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, ItalyAzienda Sanitaria Territoriale Pesaro-Urbino, Pesaro, ItalyDepartment of Dermatology, Skin Center Senigallia, Ancona, ItalyDermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, ItalyDermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, ItalyIDI-IRCCS, Dermatological Research Hospital, Rome, ItalyDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy IDI-IRCCS, Dermatological Research Hospital, Rome, ItalyDermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, ItalyDermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, ItalyDermatology Section, Department of Medical, Surgical, and Neurological Sciences, Santa Maria Alle Scotte Hospital, Siena, ItalySchool of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Dermatology Clinic, IRCCS San Raffaele Scientific Institute, Milan, ItalyAzienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Skin Cancer Center, Reggio Emilia, ItalyDermatology Section, Department of Medical, Surgical, and Neurological Sciences, Santa Maria Alle Scotte Hospital, Siena, ItalyDermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy Introduction: Magnified dermoscopy (MD), or optical super-high magnification dermoscopy is an emerging technique in dermatology. Objectives: The study aims to evaluate the distribution of conventional dermoscopy, MD, and reflectance confocal microscopy (RCM) features in dermoscopically equivocal pigmented lesions and to estimate their diagnostic accuracy. Methods :A retrospective analysis of conventional dermoscopic (´20), MD (´400) and RCM  pictures of dermoscopically equivocal pigmented lesions, diagnosed as either nevi or melanoma, was performed. Distribution of features, sensitivity, and specificity for dermoscopy, MD, RCM and a combination of these last 2 with conventional dermoscopy were estimated. Results: A total of 74 nevi and 20 melanomas were included in the analysis. A positive correlation was observed between a 7-point checklist in conventional dermoscopy and the diagnosis of melanoma. With MD, a significant correlation between dots, non-edged papillae, and melanoma was observed, but the technique did not significantly impact diagnostic accuracy as compared to traditional dermoscopy. On the other hand, RCM, alone or in combimation with traditional dermoscopy, iincreased diagnostic accuracy, in particular, specificity for melanoma diagnosis. Conclusions: RCM has a defined role in increasing diagnostic accuracy of doubtful dermoscopic lesions while the role of MD in clinical practice has yet to be defined and methodologic standardization as well as a revision of terminology is encouraged to improve the recognition of features. https://dpcj.org/index.php/dpc/article/view/5253Magnified dermoscopyReflectance confocal microscopyDiagnostic accuracyMelanomaMelanocytic lesions
spellingShingle Stefania Guida
Silvana Ciardo
Shaniko Kaleci
Francesca Farnetani
Marco Spadafora
Giulia Radi
Renato Rossi
Elisa Molinelli
Sabrina Longhitano
Claudio Conforti
Carmen Cantisani
Camilla Chello
Oriana Simonetti
Anna Maria Offidani
Pietro Rubegni
Franco Rongioletti
Caterina Longo
Elisa Cinotti
Giovanni Pellacani
Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
Dermatology Practical & Conceptual
Magnified dermoscopy
Reflectance confocal microscopy
Diagnostic accuracy
Melanoma
Melanocytic lesions
title Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
title_full Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
title_fullStr Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
title_full_unstemmed Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
title_short Diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
title_sort diagnostic accuracy of magnified dermoscopy and reflectance confocal microscopy in assessing melanocytic lesions
topic Magnified dermoscopy
Reflectance confocal microscopy
Diagnostic accuracy
Melanoma
Melanocytic lesions
url https://dpcj.org/index.php/dpc/article/view/5253
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