Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy
Background. Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hy...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8875257 |
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| author | A. Bove C. Dei Rocini R. M. Di Renzo M. Farrukh G. Palone S. Chiarini T. Staniscia |
| author_facet | A. Bove C. Dei Rocini R. M. Di Renzo M. Farrukh G. Palone S. Chiarini T. Staniscia |
| author_sort | A. Bove |
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| description | Background. Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia. Methods. This is a prospective cohort study which was conducted between January 2016 and April 2019. A total of 177 consecutive patients (141 (79.7%) women and 36 (20.3%) men) who underwent TT were included in the current study. Hypocalcemia occurred when serum calcium levels were below 8.0 mg/dL or 1.10 mmol/L. Patients were divided into two groups (Group 1, normocalcemic; Group 2, hypocalcemic) and were assessed taking into consideration preoperative serum 25-hydroxy vitamin D (25-OHD) levels, preoperative serum calcium levels, thyroid hormone levels, sex, body mass index (BMI), and smoking habits. Vitamin D deficiency was defined as 25-OHD levels <25 ng/mL. Results. The incidence of postoperative asymptomatic and symptomatic hypocalcemia in the two groups was 19.8% and 15.8%, respectively. Preoperative 25-OHD level was significantly different between Group 1 and Group 2 (31.5 ± 15.0 ng/mL vs 18.7 ± 9.8 ng/mL,p=0.017). Logistic regression analysis revealed that preoperative vitamin D deficiency was a significant predictive factor of postoperative hypocalcemia (p=0.012), and, specifically, the risk of hypocalcemia increased 15-fold in patients with a preoperative vitamin D level <25 ng/mL (odds ratio [OR], 14.8). Conclusions. Postoperative hypocalcemia is significantly associated with low preoperative levels of serum 25-OHD. Our studies demonstrate that vitamin D deficiency (<25 ng/mL) is an independent predictive factor of postoperative hypocalcemia. |
| format | Article |
| id | doaj-art-23114d65e6944e8997ba8a8cd9fafa1b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-23114d65e6944e8997ba8a8cd9fafa1b2025-08-20T03:54:48ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/88752578875257Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total ThyroidectomyA. Bove0C. Dei Rocini1R. M. Di Renzo2M. Farrukh3G. Palone4S. Chiarini5T. Staniscia6Department of Medicine, Dentistry and Biotechnology, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medicine, Dentistry and Biotechnology, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medicine, Dentistry and Biotechnology, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medicine, Dentistry and Biotechnology, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medicine, Dentistry and Biotechnology, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medicine and Ageing Sciences, University “G. D’Annunzio”, Chieti-Pescara, ItalyDepartment of Medicine and Ageing Sciences, University “G. D’Annunzio”, Chieti-Pescara, ItalyBackground. Total thyroidectomy (TT) is recommended in the treatment of malignant and benignant thyroid diseases, and, to date, transient hypocalcemia is the most frequent complication after the procedure. We prospectively evaluated the role of vitamin D deficiency as a predictor of postoperative hypocalcemia. Methods. This is a prospective cohort study which was conducted between January 2016 and April 2019. A total of 177 consecutive patients (141 (79.7%) women and 36 (20.3%) men) who underwent TT were included in the current study. Hypocalcemia occurred when serum calcium levels were below 8.0 mg/dL or 1.10 mmol/L. Patients were divided into two groups (Group 1, normocalcemic; Group 2, hypocalcemic) and were assessed taking into consideration preoperative serum 25-hydroxy vitamin D (25-OHD) levels, preoperative serum calcium levels, thyroid hormone levels, sex, body mass index (BMI), and smoking habits. Vitamin D deficiency was defined as 25-OHD levels <25 ng/mL. Results. The incidence of postoperative asymptomatic and symptomatic hypocalcemia in the two groups was 19.8% and 15.8%, respectively. Preoperative 25-OHD level was significantly different between Group 1 and Group 2 (31.5 ± 15.0 ng/mL vs 18.7 ± 9.8 ng/mL,p=0.017). Logistic regression analysis revealed that preoperative vitamin D deficiency was a significant predictive factor of postoperative hypocalcemia (p=0.012), and, specifically, the risk of hypocalcemia increased 15-fold in patients with a preoperative vitamin D level <25 ng/mL (odds ratio [OR], 14.8). Conclusions. Postoperative hypocalcemia is significantly associated with low preoperative levels of serum 25-OHD. Our studies demonstrate that vitamin D deficiency (<25 ng/mL) is an independent predictive factor of postoperative hypocalcemia.http://dx.doi.org/10.1155/2020/8875257 |
| spellingShingle | A. Bove C. Dei Rocini R. M. Di Renzo M. Farrukh G. Palone S. Chiarini T. Staniscia Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy International Journal of Endocrinology |
| title | Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy |
| title_full | Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy |
| title_fullStr | Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy |
| title_full_unstemmed | Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy |
| title_short | Vitamin D Deficiency as a Predictive Factor of Transient Hypocalcemia after Total Thyroidectomy |
| title_sort | vitamin d deficiency as a predictive factor of transient hypocalcemia after total thyroidectomy |
| url | http://dx.doi.org/10.1155/2020/8875257 |
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