Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis
<b>Background/Objectives:</b> There is a high prevalence of sleep behaviour disorders, as well as sleep disordered breathing (SDB), in individuals living with sickle cell disease (SCD). SDB has been systematically reviewed; therefore, this systematic review and meta-analysis focused on s...
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MDPI AG
2024-12-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/1/21 |
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| author | Melanie Koelbel Fenella J. Kirkham |
| author_facet | Melanie Koelbel Fenella J. Kirkham |
| author_sort | Melanie Koelbel |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> There is a high prevalence of sleep behaviour disorders, as well as sleep disordered breathing (SDB), in individuals living with sickle cell disease (SCD). SDB has been systematically reviewed; therefore, this systematic review and meta-analysis focused on sleep behaviour. <b>Methods:</b> The comprehensive literature search, following PRISMA reporting guidelines, included all languages, conference proceedings and published theses from inception through February 2022. We identified 31 studies, with most of the research being conducted in North America, using polysomnography, actigraphy and questionnaires/diaries in paediatric SCD cohorts. <b>Results:</b> Total sleep time (TST) decreased, while sleep onset latency (SOL) increased with age. TST was higher on self-reported sleep diary measures and lower on polysomnography (PSG) and actigraphy assessments. SOL was lowest during PSG and highest in actigraphy. The discrepancy between sleep measures might be due to the overestimation of sleep behaviour by parents. In six studies, TST and SOL were compared between people living with SCD and healthy controls; in four, TST was longer in those living with SCD while it was shorter in two. Meta-analyses on the effect of TST and SOL were limited due to publication bias, with heterogeneity between the studies, in part related to measurement differences. No significant differences were found. <b>Conclusions:</b> The scarcity of case-control studies and significant heterogeneity in findings likely attributable to variations in sleep assessment methodologies. Gaps in the literature should be addressed. |
| format | Article |
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| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Children |
| spelling | doaj-art-230ec42210b849a2b0f20dd3014e8b9a2025-01-24T13:27:01ZengMDPI AGChildren2227-90672024-12-011212110.3390/children12010021Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-AnalysisMelanie Koelbel0Fenella J. Kirkham1Developmental Neurosciences Unit, Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UKDevelopmental Neurosciences Unit, Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK<b>Background/Objectives:</b> There is a high prevalence of sleep behaviour disorders, as well as sleep disordered breathing (SDB), in individuals living with sickle cell disease (SCD). SDB has been systematically reviewed; therefore, this systematic review and meta-analysis focused on sleep behaviour. <b>Methods:</b> The comprehensive literature search, following PRISMA reporting guidelines, included all languages, conference proceedings and published theses from inception through February 2022. We identified 31 studies, with most of the research being conducted in North America, using polysomnography, actigraphy and questionnaires/diaries in paediatric SCD cohorts. <b>Results:</b> Total sleep time (TST) decreased, while sleep onset latency (SOL) increased with age. TST was higher on self-reported sleep diary measures and lower on polysomnography (PSG) and actigraphy assessments. SOL was lowest during PSG and highest in actigraphy. The discrepancy between sleep measures might be due to the overestimation of sleep behaviour by parents. In six studies, TST and SOL were compared between people living with SCD and healthy controls; in four, TST was longer in those living with SCD while it was shorter in two. Meta-analyses on the effect of TST and SOL were limited due to publication bias, with heterogeneity between the studies, in part related to measurement differences. No significant differences were found. <b>Conclusions:</b> The scarcity of case-control studies and significant heterogeneity in findings likely attributable to variations in sleep assessment methodologies. Gaps in the literature should be addressed.https://www.mdpi.com/2227-9067/12/1/21sickle cell diseasesleep behaviour disorderspolysomnographyactigraphysleep diarytotal sleep time |
| spellingShingle | Melanie Koelbel Fenella J. Kirkham Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis Children sickle cell disease sleep behaviour disorders polysomnography actigraphy sleep diary total sleep time |
| title | Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis |
| title_full | Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis |
| title_short | Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis |
| title_sort | sleep behaviour in sickle cell disease a systematic review and meta analysis |
| topic | sickle cell disease sleep behaviour disorders polysomnography actigraphy sleep diary total sleep time |
| url | https://www.mdpi.com/2227-9067/12/1/21 |
| work_keys_str_mv | AT melaniekoelbel sleepbehaviourinsicklecelldiseaseasystematicreviewandmetaanalysis AT fenellajkirkham sleepbehaviourinsicklecelldiseaseasystematicreviewandmetaanalysis |