Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09
Four new lactones, including hypomonacid A (1) and hypomonone A–C (4–6), as well as nine known polyketide analogues (2–3 and 7–13) were obtained from endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. Their planar structures were extensively established by analysing HRESIMS and...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-04-01
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| Series: | Mycology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21501203.2024.2397600 |
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| _version_ | 1849328781756465152 |
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| author | Xin Ouyang Senhua Chen Qiling Chen Heng Guo Lan Liu Hongju Liu Chong Yan |
| author_facet | Xin Ouyang Senhua Chen Qiling Chen Heng Guo Lan Liu Hongju Liu Chong Yan |
| author_sort | Xin Ouyang |
| collection | DOAJ |
| description | Four new lactones, including hypomonacid A (1) and hypomonone A–C (4–6), as well as nine known polyketide analogues (2–3 and 7–13) were obtained from endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher’s method in combination with quantum-chemical ECD calculation. In addition, compounds 1 and 2 showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound 1 inhibited the production of LPS-stimulated inflammation in mouse macrophage RAW264.7 cells by suppressing the expression of iNOS, TNF-α, IL-1β, and IL-6. |
| format | Article |
| id | doaj-art-230ae70c19c34ff69d0c98b551900486 |
| institution | Kabale University |
| issn | 2150-1203 2150-1211 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Mycology |
| spelling | doaj-art-230ae70c19c34ff69d0c98b5519004862025-08-20T03:47:28ZengTaylor & Francis GroupMycology2150-12032150-12112025-04-0116291892810.1080/21501203.2024.2397600Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09Xin Ouyang0Senhua Chen1Qiling Chen2Heng Guo3Lan Liu4Hongju Liu5Chong Yan6School of Pharmacy, Guangdong Medical University, Dongguan, ChinaSchool of Marine Sciences, Sun Yat-sen University, Zhuhai, ChinaSchool of Pharmacy, Guangdong Medical University, Dongguan, ChinaSchool of Marine Sciences, Sun Yat-sen University, Zhuhai, ChinaSchool of Marine Sciences, Sun Yat-sen University, Zhuhai, ChinaSchool of Pharmacy, Guangdong Medical University, Dongguan, ChinaSchool of Pharmacy, Guangdong Medical University, Dongguan, ChinaFour new lactones, including hypomonacid A (1) and hypomonone A–C (4–6), as well as nine known polyketide analogues (2–3 and 7–13) were obtained from endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher’s method in combination with quantum-chemical ECD calculation. In addition, compounds 1 and 2 showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound 1 inhibited the production of LPS-stimulated inflammation in mouse macrophage RAW264.7 cells by suppressing the expression of iNOS, TNF-α, IL-1β, and IL-6.https://www.tandfonline.com/doi/10.1080/21501203.2024.2397600Polyketidesendophytic fungusHypomontagnella sp.anti-inflammatory activity |
| spellingShingle | Xin Ouyang Senhua Chen Qiling Chen Heng Guo Lan Liu Hongju Liu Chong Yan Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 Mycology Polyketides endophytic fungus Hypomontagnella sp. anti-inflammatory activity |
| title | Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 |
| title_full | Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 |
| title_fullStr | Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 |
| title_full_unstemmed | Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 |
| title_short | Anti-inflammatory polyketides from Santalum album derived endophytic fungus Hypomontagnella sp. TX-09 |
| title_sort | anti inflammatory polyketides from santalum album derived endophytic fungus hypomontagnella sp tx 09 |
| topic | Polyketides endophytic fungus Hypomontagnella sp. anti-inflammatory activity |
| url | https://www.tandfonline.com/doi/10.1080/21501203.2024.2397600 |
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